PMID- 28754310
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20231213
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 77
IP  - 5
DP  - 2017 Nov
TI  - A single-institution assessment of superficial spreading melanoma (SSM) in the 
      pediatric population: Molecular and histopathologic features compared with adult 
      SSM.
PG  - 886-892
LID - S0190-9622(17)31807-8 [pii]
LID - 10.1016/j.jaad.2017.05.051 [doi]
AB  - BACKGROUND: The epidemiology of pediatric melanoma is distinct from that seen in 
      adults. This is more distinguishable when pediatric patients are separated into 
      prepubertal and adolescent groups. OBJECTIVE: In this study, we compared 
      epidemiologic, clinical, histologic, and molecular characteristics of pediatric 
      superficial spreading melanoma (SSM) in prepubertal and adolescent patients to 
      that in adults. METHOD: We reviewed our database for pediatric melanomas, 
      comparing SSM data between pediatric and adult cases for pathologic stage at 
      presentation, ratio of radial to vertical growth phase, average Breslow depth and 
      mitotic index, and frequency of fluorescence in situ hybridization (FISH) 
      positivity. RESULTS: Of 84 pediatric melanomas, 38 were SSM, and 5 of the latter 
      (6%) were prepubertal. There were no significant differences when pediatric and 
      adult SSM were compared for stage at presentation, ratio of radial to vertical 
      growth phase, average Breslow depth and mitotic count, or frequency of FISH 
      positivity. A significant difference was detected for SSM arising from a 
      precursor nevus (80% of pediatric cases versus 30% of adult cases). LIMITATIONS: 
      Follow-up time was limited for both cohorts. CONCLUSIONS: SSM melanoma is 
      infrequent in childhood, particularly in the prepubertal years. Features such as 
      tumor stage, Breslow depth, mitotic activity, and FISH positivity suggest 
      morphologic and molecular characteristics similar to those of adult SSM.
CI  - Copyright (c) 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. 
      All rights reserved.
FAU - Verzi, Anna Elisa
AU  - Verzi AE
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois.
FAU - Bubley, Jeffrey A
AU  - Bubley JA
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois.
FAU - Haugh, Alexandra M
AU  - Haugh AM
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois.
FAU - Zhang, Bin
AU  - Zhang B
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois.
FAU - Wagner, Annette
AU  - Wagner A
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital, Chicago, 
      Illinois.
FAU - Kruse, Lacey
AU  - Kruse L
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois; Ann and Robert H. Lurie Children's Hospital, Chicago, 
      Illinois.
FAU - West, Dennis P
AU  - West DP
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois.
FAU - Wayne, Jeffrey
AU  - Wayne J
AD  - Department of Surgery, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois.
FAU - Guitart, Joan
AU  - Guitart J
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois.
FAU - Gerami, Pedram
AU  - Gerami P
AD  - Department of Dermatology, Feinberg School of Medicine, Northwestern University, 
      Chicago, Illinois; Robert H. Lurie Cancer Center, Northwestern University, 
      Chicago, Illinois. Electronic address: pgerami1@nm.org.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170725
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Biopsy, Needle
MH  - Child
MH  - Cohort Studies
MH  - Databases, Factual
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Melanoma/epidemiology/*genetics/*pathology
MH  - Middle Aged
MH  - Neoplasm Invasiveness/pathology
MH  - Neoplasm Staging
MH  - Nevus, Pigmented/epidemiology/*genetics/*pathology
MH  - Precancerous Conditions/pathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sex Factors
MH  - Skin Neoplasms/epidemiology/*genetics/*pathology
MH  - Survival Rate
MH  - Melanoma, Cutaneous Malignant
OTO - NOTNLM
OT  - FISH
OT  - adolescent
OT  - children
OT  - radial growth phase
OT  - superficial spreading melanoma
OT  - vertical growth phase
EDAT- 2017/07/30 06:00
MHDA- 2017/11/03 06:00
CRDT- 2017/07/30 06:00
PHST- 2016/12/15 00:00 [received]
PHST- 2017/05/26 00:00 [revised]
PHST- 2017/05/31 00:00 [accepted]
PHST- 2017/07/30 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
PHST- 2017/07/30 06:00 [entrez]
AID - S0190-9622(17)31807-8 [pii]
AID - 10.1016/j.jaad.2017.05.051 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2017 Nov;77(5):886-892. doi: 10.1016/j.jaad.2017.05.051. Epub 
      2017 Jul 25.