PMID- 28754344 OWN - NLM STAT- MEDLINE DCOM- 20180405 LR - 20180816 IS - 1872-7972 (Electronic) IS - 0304-3940 (Linking) VI - 656 DP - 2017 Aug 24 TI - The effect of childhood trauma on serum BDNF in bipolar depression is modulated by the serotonin promoter genotype. PG - 177-181 LID - S0304-3940(17)30615-8 [pii] LID - 10.1016/j.neulet.2017.07.043 [doi] AB - In healthy humans, both childhood trauma and the short form of the serotonin promoter transporter genotype (5-HTTLPR) are associated with lower levels of brain-derived neurotrophic factor (BDNF). In subjects with bipolar disorder (BD), lower levels of BDNF and a higher degree of childhood trauma were observed compared with healthy controls. However, is still unknown if the functional 5-HTTLPR polymorphisms exerts an effect on both abnormalities. In 40 inpatients affected by a major depressive episode in the course of BD, we genotyped 5-HTTLPR, measured serum BDNF with ELISA, and assessed early adversities by the childhood trauma questionnaire (CTQ). Data were analyzed in the context of the general linear model correcting for age, sex, ongoing lithium treatment, severity of current depression, and CTQ minimization/denial scores to investigate the effect of 5-HTTLPR polymorphism and childhood trauma on BDNF levels. Early trauma were negatively associated with BDNF serum levels (higher CTQ scores, lower BDNF; p=0.0019). 5-HTTLPR l/l homozygotes showed significantly higher BDNF levels than 5-HTTLPR*s carriers (30.57+/-6.13 vs 26.82+/-6.41; p=0.0309). A separate-slopes analysis showed that 5-HTTLPR significantly influenced the relationship between early trauma and adult BDNF (interaction of 5-HTTLPR with CTQ scores: p=0.0023), due to a significant relationship between trauma and BDNF in 5-HTTLPR*s carriers, but not among l/l homozygotes. Putatively detrimental effects of childhood trauma exposure on adult BDNF serum levels are influenced by 5-HTTLPR genotype in patients affected by BD. Possible mechanisms include epigenetic modulation of BDNF gene expression, due to different reactivity to stressors in 5-HTTLPR genotype groups. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Benedetti, Francesco AU - Benedetti F AD - Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano and University Vita-Salute San Raffaele, Milano, Italy. Electronic address: benedetti.francesco@hsr.it. FAU - Ambree, Oliver AU - Ambree O AD - Department of Psychiatry, University of Munster, Munster, Germany. FAU - Locatelli, Clara AU - Locatelli C AD - Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano and University Vita-Salute San Raffaele, Milano, Italy. FAU - Lorenzi, Cristina AU - Lorenzi C AD - Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano and University Vita-Salute San Raffaele, Milano, Italy. FAU - Poletti, Sara AU - Poletti S AD - Department of Psychiatry, University of Munster, Munster, Germany. FAU - Colombo, Cristina AU - Colombo C AD - Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano and University Vita-Salute San Raffaele, Milano, Italy. FAU - Arolt, Volker AU - Arolt V AD - Department of Psychiatry, University of Munster, Munster, Germany. LA - eng PT - Journal Article DEP - 20170725 PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (SLC6A4 protein, human) RN - 0 (Serotonin Plasma Membrane Transport Proteins) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Bipolar Disorder/*blood/genetics/psychology MH - Brain-Derived Neurotrophic Factor/*blood MH - Child MH - *Child Abuse MH - Epigenesis, Genetic MH - Female MH - Genotype MH - Humans MH - Male MH - Middle Aged MH - Promoter Regions, Genetic MH - Serotonin Plasma Membrane Transport Proteins/*genetics OTO - NOTNLM OT - BDNF OT - Bipolar disorder OT - Childhood trauma OT - Serotonin promoter EDAT- 2017/07/30 06:00 MHDA- 2018/04/06 06:00 CRDT- 2017/07/30 06:00 PHST- 2017/03/06 00:00 [received] PHST- 2017/07/14 00:00 [revised] PHST- 2017/07/24 00:00 [accepted] PHST- 2017/07/30 06:00 [pubmed] PHST- 2018/04/06 06:00 [medline] PHST- 2017/07/30 06:00 [entrez] AID - S0304-3940(17)30615-8 [pii] AID - 10.1016/j.neulet.2017.07.043 [doi] PST - ppublish SO - Neurosci Lett. 2017 Aug 24;656:177-181. doi: 10.1016/j.neulet.2017.07.043. Epub 2017 Jul 25.