PMID- 28755388
OWN - NLM
STAT- MEDLINE
DCOM- 20171120
LR  - 20210317
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 152
IP  - 4
DP  - 2017 Dec
TI  - Killer-cell immunoglobulin-like receptors on the cusp of modern immunogenetics.
PG  - 556-561
LID - 10.1111/imm.12802 [doi]
AB  - Killer-cell immunoglobulin-like receptors (KIR) and their human leukocyte antigen 
      (HLA) ligands play a central role in immunity and human health. These molecules 
      are encoded by gene families with copy number variation, extreme levels of 
      sequence diversity and complex expression patterns. The rapid evolution of KIR 
      and HLA genes and their associations with infectious diseases, pregnancy 
      disorders, immunopathologies and outcome of cell transplantation have generated 
      considerable interest from immunologists, geneticists and clinicians. Until 
      recently, however, analyses have been stuck at low-level resolution, focusing 
      primarily on presence or absence of KIR genes. This is changing with the advent 
      of modern high throughput sequencing, cell phenotyping and bioinformatics. These 
      developments allow high-resolution analysis and much deeper understanding of KIR 
      evolution and KIR function. The impending deluge of high dimensional data brings 
      inevitably new challenges in analysis, interpretation and communication of 
      results, but the benefits are already tangible. The diversity of KIR across 
      worldwide human populations is being catalogued at the allele level. Structures 
      of KIR molecules and their interactions with HLA-peptide complexes are being 
      determined. How KIR modulate natural killer cell education is being defined. 
      Ligands for activating KIR, elusive for many years, are being discovered. KIR 
      gene complexes and their related receptor gene families are being characterized 
      in animal models and livestock breeds. These advances are helping to generate a 
      more complete picture of the impact of KIR variation in health and disease and 
      offer new opportunities for immunotherapy, as highlighted in a recent meeting 
      (The Tenth KIR Workshop, April 2017 Cambridge, UK).
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Colucci, Francesco
AU  - Colucci F
AUID- ORCID: 0000-0001-5193-6376
AD  - Department of Obstetrics and Gynaecology, National Institute for Health Research 
      Cambridge Biomedical Research Centre, University of Cambridge School of Clinical 
      Medicine, Cambridge, UK.
AD  - Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.
FAU - Traherne, James
AU  - Traherne J
AD  - Department of Pathology, University of Cambridge, Cambridge, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 200841/Z/16/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20170912
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
SB  - IM
EIN - Immunology. 2019 Apr;156(4):422. PMID: 30873604
MH  - Animals
MH  - Female
MH  - *HLA Antigens/genetics/immunology
MH  - Humans
MH  - *Immunogenetic Phenomena
MH  - *Infections/genetics/immunology
MH  - Killer Cells, Natural/*immunology
MH  - Male
MH  - Pregnancy
MH  - *Receptors, KIR/genetics/immunology
PMC - PMC5680062
OTO - NOTNLM
OT  - Genomics
OT  - Killer-cell immunoglobulin-like receptors
OT  - MHC/HLA
OT  - natural killer cell
EDAT- 2017/07/30 06:00
MHDA- 2017/11/29 06:00
PMCR- 2018/12/01
CRDT- 2017/07/30 06:00
PHST- 2017/06/30 00:00 [received]
PHST- 2017/07/25 00:00 [revised]
PHST- 2017/07/25 00:00 [accepted]
PHST- 2017/07/30 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/07/30 06:00 [entrez]
PHST- 2018/12/01 00:00 [pmc-release]
AID - IMM12802 [pii]
AID - 10.1111/imm.12802 [doi]
PST - ppublish
SO  - Immunology. 2017 Dec;152(4):556-561. doi: 10.1111/imm.12802. Epub 2017 Sep 12.