PMID- 28755842
OWN - NLM
STAT- MEDLINE
DCOM- 20180808
LR  - 20180808
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 11 Suppl 2
DP  - 2017 Dec
TI  - High serum ferritin levels are associated with insulin resistance but not with 
      impaired glucose tolerance in a healthy people population.
PG  - S983-S988
LID - S1871-4021(17)30218-7 [pii]
LID - 10.1016/j.dsx.2017.07.026 [doi]
AB  - AIM: To assess the association between elevated serum ferritin levels and the 
      presence of insulin resistance (IR) or impaired glucose tolerance (IGT) in a 
      population of individuals with no endocrine or metabolic disorders background. 
      METHODS: Analytical cross-sectional study, carried out in adults of both sexes 
      with no medical history of type 2 diabetes mellitus (T2DM) or other metabolic or 
      endocrine disorder, who attended the outpatient service of a private clinic in 
      Lima-Peru during 2012-2014 period. Impaired serum ferritin levels were defined as 
      serum ferritin values >300mug/L in men and >200mug/L in women. IR was defined as a 
      Homeostasis Model Assessment (HOMA-IR) value >/=3.8 and IGT was defined as an oral 
      glucose tolerance test (OGTT) value between 126mg/dL and 199mg/dL. The reported 
      association measure was the prevalence ratio (PR) with their respective 95% 
      confidence intervals (95% CI). RESULTS: We analyzed 213 participants, the average 
      age was 35.8+/-11.1years and 35.7% were males. The prevalence of impaired serum 
      ferritin levels, IR and IGT in the population was 12.7%, 33.3% and 9.9% 
      respectively. In the adjusted Poisson regression models, the prevalence of IR was 
      higher among the group with impaired serum ferritin levels (PR=1.74; 
      95%CI:1.18-2.56); however, we found no association between impaired serum 
      ferritin levels and IGT (PR=1.42; 95%CI:0.47-4.30). CONCLUSIONS: Impaired levels 
      of serum ferritin are associated with IR, nevertheless, not with IGT in a 
      metabolically healthy population. Serum ferritin could be considered as an early 
      marker of IR prior to the onset of glycaemia disorders.
CI  - Copyright (c) 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Aguirre, Luis G
AU  - Aguirre LG
AD  - Sociedad Cientifica de Estudiantes de Medicina de la Universidad de San Martin de 
      Porres, Universidad de San Martin de Porres, Lima, Peru.
FAU - Urrunaga-Pastor, Diego
AU  - Urrunaga-Pastor D
AD  - Sociedad Cientifica de Estudiantes de Medicina de la Universidad de San Martin de 
      Porres, Universidad de San Martin de Porres, Lima, Peru.
FAU - Moncada-Mapelli, Enrique
AU  - Moncada-Mapelli E
AD  - Sociedad Cientifica de Estudiantes de Medicina de la Universidad de San Martin de 
      Porres, Universidad de San Martin de Porres, Lima, Peru.
FAU - Guarnizo-Poma, Mirella
AU  - Guarnizo-Poma M
AD  - Instituto Medico de la Mujer, Instituto Medico Metabolico, Lima, Peru.
FAU - Lazaro-Alcantara, Herbert
AU  - Lazaro-Alcantara H
AD  - Instituto Medico de la Mujer, Instituto Medico Metabolico, Lima, Peru.
FAU - Benites-Zapata, Vicente A
AU  - Benites-Zapata VA
AD  - Centre for Public Health Research, Research Institute, Faculty of Medicine, 
      Universidad de San Martin de Porres, Lima, Peru. Electronic address: 
      vbeniteszapata@gmail.com.
CN  - Insulin Resistance and Metabolic Syndrome Research Group
LA  - eng
PT  - Journal Article
DEP - 20170720
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Ferritins/*blood
MH  - Glucose Intolerance/*etiology
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Adults
OT  - Ferritin
OT  - Glucose tolerance test
OT  - Insulin resistance
EDAT- 2017/08/02 06:00
MHDA- 2018/08/09 06:00
CRDT- 2017/07/31 06:00
PHST- 2017/07/02 00:00 [received]
PHST- 2017/07/16 00:00 [accepted]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/08/09 06:00 [medline]
PHST- 2017/07/31 06:00 [entrez]
AID - S1871-4021(17)30218-7 [pii]
AID - 10.1016/j.dsx.2017.07.026 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S983-S988. doi: 
      10.1016/j.dsx.2017.07.026. Epub 2017 Jul 20.