PMID- 28755853
OWN - NLM
STAT- MEDLINE
DCOM- 20190131
LR  - 20200306
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Print)
IS  - 0028-3932 (Linking)
VI  - 110
DP  - 2018 Feb
TI  - Search and recovery of autobiographical and laboratory memories: Shared and 
      distinct neural components.
PG  - 44-54
LID - S0028-3932(17)30281-6 [pii]
LID - 10.1016/j.neuropsychologia.2017.07.030 [doi]
AB  - Functional neuroimaging evidence suggests that there are differences in the 
      neural correlates of episodic memory for laboratory stimuli (laboratory memory) 
      and for events from one's own life (autobiographical memory). However, this 
      evidence is scarce and often confounded with differences in memory testing 
      procedures. Here, we directly compared the neural mechanisms underlying the 
      search and recovery of autobiographical and laboratory memories while minimizing 
      testing differences. Before scanning, participants completed a laboratory memory 
      encoding task in which they studied four-word "chains" spread across three word 
      pairs. During scanning, participants completed a laboratory memory retrieval 
      task, in which they recalled the word chains, and an autobiographical memory 
      retrieval task, in which they recalled specific personal events associated with 
      word cues. Importantly, response times were similar in the two tasks, allowing 
      for a direct comparison of the activation time courses. We found that during 
      memory search (searching for the memory target), similar brain regions were 
      activated during both the autobiographical and laboratory tasks, whereas during 
      memory recovery (accessing the memory traces; i.e., ecphory), clear differences 
      emerged: regions of the default mode network (DMN) were activated greater during 
      autobiographical than laboratory memory, whereas the bilateral superior parietal 
      lobules were activated greater during laboratory than autobiographical memory. 
      Also, multivariate functional connectivity analyses revealed that regardless of 
      memory stage, the DMN and ventral attention network exhibited a more integrated 
      topology in the functional network underlying autobiographical (vs. laboratory) 
      memory retrieval, whereas the fronto-parietal task control network exhibited a 
      more integrated topology in the functional network underlying laboratory (vs. 
      autobiographical) memory retrieval. These findings further characterize the 
      shared and distinct neural components underlying autobiographical and laboratory 
      memories, and suggest that differences in autobiographical vs. laboratory memory 
      brain activation previously reported in the literature reflect memory recovery 
      rather than search differences.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Monge, Zachary A
AU  - Monge ZA
AD  - Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, United 
      States. Electronic address: zachary.monge@duke.edu.
FAU - Wing, Erik A
AU  - Wing EA
AD  - Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, United 
      States. Electronic address: erik.wing@duke.edu.
FAU - Stokes, Jared
AU  - Stokes J
AD  - Department of Psychology, University of California, Davis, Davis, CA 95616, 
      United States. Electronic address: jdstokes@ucdavis.edu.
FAU - Cabeza, Roberto
AU  - Cabeza R
AD  - Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, United 
      States. Electronic address: cabeza@duke.edu.
LA  - eng
GR  - R01 AG019731/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170726
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
SB  - IM
MH  - Association Learning/*physiology
MH  - Brain/diagnostic imaging/*physiology
MH  - Brain Mapping
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Memory, Episodic
MH  - Neural Pathways/diagnostic imaging/physiology
MH  - Pattern Recognition, Visual/physiology
MH  - Reading
MH  - Self Concept
MH  - Young Adult
PMC - PMC5785570
MID - NIHMS896543
OTO - NOTNLM
OT  - Autobiographical memory
OT  - Default mode network
OT  - Episodic memory
OT  - Functional MRI
OT  - Functional connectivity
OT  - Graph theory
EDAT- 2017/08/02 06:00
MHDA- 2019/02/01 06:00
PMCR- 2019/02/01
CRDT- 2017/07/31 06:00
PHST- 2017/04/06 00:00 [received]
PHST- 2017/07/19 00:00 [revised]
PHST- 2017/07/25 00:00 [accepted]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2019/02/01 06:00 [medline]
PHST- 2017/07/31 06:00 [entrez]
PHST- 2019/02/01 00:00 [pmc-release]
AID - S0028-3932(17)30281-6 [pii]
AID - 10.1016/j.neuropsychologia.2017.07.030 [doi]
PST - ppublish
SO  - Neuropsychologia. 2018 Feb;110:44-54. doi: 
      10.1016/j.neuropsychologia.2017.07.030. Epub 2017 Jul 26.