PMID- 28755988
OWN - NLM
STAT- MEDLINE
DCOM- 20180605
LR  - 20181113
IS  - 1545-7214 (Electronic)
IS  - 1064-7481 (Print)
IS  - 1064-7481 (Linking)
VI  - 25
IP  - 11
DP  - 2017 Nov
TI  - Acute Affective Reactivity and Quality of Life in Older Adults with Amnestic Mild 
      Cognitive Impairment: A Functional MRI Study.
PG  - 1225-1233
LID - S1064-7481(17)30376-7 [pii]
LID - 10.1016/j.jagp.2017.06.019 [doi]
AB  - OBJECTIVES: Poor quality of life (QoL) is a major concern among older adults with 
      amnestic mild cognitive impairment (MCI). Maladaptive affective regulation and 
      its relevant frontal dysfunction that are often observed in older adults with MCI 
      may provide an insight into the understanding of their QoL. METHODS: In this 
      case-controlled study, participants (MCI patients, N = 18; healthy comparisons 
      [HC], N = 21) completed cognitive tasks, and underwent resting-state functional 
      magnetic resonance imaging (rs-fMRI) immediately before and after the tasks. The 
      amplitude of low-frequency fluctuations (ALFF) of rs-fMRI signals was calculated 
      to examine the brain's spontaneous activity. The change in valence from the 
      Self-Assessment Manikin indexed affective reactivity. QoL was assessed using 
      Quality of Life-AD measure. Multiple mediator model was used to examine the 
      mediating effect of frontal regions' ALFF reactivity between the affective 
      reactivity and QoL. RESULTS: The MCI group had significantly worse QoL and more 
      negative affective reactivity than HC group. Less negative affective reactivity 
      was significantly associated with better QoL in MCI not HC. ALFF in the anterior 
      cingulate cortex, medial prefrontal cortex (MPFC), and superior frontal gyrus 
      (SFG) increased significantly less after cognitive tasks in MCI than HC. For the 
      entire sample, greater increases of ALFF in MPFC and SFG were significantly 
      associated with better QoL, and SFG alone significantly mediated the association 
      between affective reactivity and QoL. CONCLUSIONS: Enhancing SFG activation, 
      especially among those with MCI, may provide a therapeutic target for addressing 
      the negative impact of maladaptive affective regulation on QoL.
CI  - Copyright (c) 2017 American Association for Geriatric Psychiatry. Published by 
      Elsevier Inc. All rights reserved.
FAU - Ren, Ping
AU  - Ren P
AD  - School of Nursing, University of Rochester, Rochester, NY.
FAU - Heffner, Kathi L
AU  - Heffner KL
AD  - School of Nursing, University of Rochester, Rochester, NY; Department of 
      Psychiatry, University of Rochester, Rochester, NY.
FAU - Jacobs, Alanna
AU  - Jacobs A
AD  - School of Nursing, University of Rochester, Rochester, NY.
FAU - Lin, Feng
AU  - Lin F
AD  - School of Nursing, University of Rochester, Rochester, NY; Department of 
      Psychiatry, University of Rochester, Rochester, NY; Department of Brain and 
      Cognitive Science, University of Rochester, Rochester, NY. Electronic address: 
      vankee_lin@urmc.rochester.edu.
LA  - eng
GR  - R01 NR015452/NR/NINR NIH HHS/United States
GR  - R21 AG053193/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20170627
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American 
      Association for Geriatric Psychiatry
JID - 9309609
SB  - IM
CIN - Am J Geriatr Psychiatry. 2017 Nov;25(11):1234-1235. PMID: 28826965
MH  - Affective Symptoms/diagnostic imaging/*physiopathology
MH  - Aged
MH  - Aged, 80 and over
MH  - Amnesia/diagnostic imaging/*physiopathology
MH  - Case-Control Studies
MH  - Cognitive Dysfunction/diagnostic imaging/*physiopathology
MH  - Female
MH  - Functional Neuroimaging/*methods
MH  - Gyrus Cinguli/diagnostic imaging/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/diagnostic imaging/*physiopathology
MH  - *Quality of Life
PMC - PMC5654660
MID - NIHMS888507
OTO - NOTNLM
OT  - Quality of life
OT  - affective reactivity
OT  - low-frequency fluctuation
OT  - mild cognitive impairment
OT  - prefrontal cortex
OT  - resting-state fMRI
EDAT- 2017/08/02 06:00
MHDA- 2018/06/06 06:00
PMCR- 2018/11/01
CRDT- 2017/07/31 06:00
PHST- 2016/11/29 00:00 [received]
PHST- 2017/05/11 00:00 [revised]
PHST- 2017/06/19 00:00 [accepted]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/06/06 06:00 [medline]
PHST- 2017/07/31 06:00 [entrez]
PHST- 2018/11/01 00:00 [pmc-release]
AID - S1064-7481(17)30376-7 [pii]
AID - 10.1016/j.jagp.2017.06.019 [doi]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2017 Nov;25(11):1225-1233. doi: 
      10.1016/j.jagp.2017.06.019. Epub 2017 Jun 27.