PMID- 28756710
OWN - NLM
STAT- MEDLINE
DCOM- 20180720
LR  - 20181202
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 28
IP  - 2
DP  - 2018 Mar
TI  - Steroid therapy and renal dysfunction are independently associated with serum 
      levels of matrix metalloproteinase-3 in patients with rheumatoid arthritis.
PG  - 242-248
LID - 10.1080/14397595.2017.1354431 [doi]
AB  - OBJECTIVE: This study aimed to evaluate whether the level of serum matrix 
      metalloproteinase-3 (MMP-3), a marker of synovium inflammation, is affected by 
      clinical characteristics of patients in rheumatoid arthritis (RA) patients. 
      METHODS: We analyzed data from 1087 female patients with RA. Pearson's 
      correlation coefficients were calculated to explore associations between 
      variables. Stepwise multiple linear regression analysis was performed to evaluate 
      patient background variables that could potentially affect serum MMP-3 levels. 
      RESULTS: Serum MMP-3 was moderately correlated with C-reactive protein (CRP) (r: 
      0.478). Factors that independently influenced serum MMP-3 levels were CRP (beta: 
      0.450), prednisolone (PSL) use (beta: 0.100), estimated glomerular filtration rate 
      (eGFR) (beta: -0.085), swollen joint count assessed on 28 joints (beta: 0.072), and 
      body mass index (beta: -0.061) in female patients with RA. In RA patients with PSL 
      use, factors that independently influenced serum MMP-3 levels were CRP (beta: 
      0.480), eGFR (beta: -0.175), and PSL dose (beta: 0.171). CONCLUSIONS: Our findings 
      suggest that steroid therapy and renal dysfunction affect serum MMP-3 levels in 
      patients with RA.
FAU - Hattori, Yosuke
AU  - Hattori Y
AD  - a Orthopaedic Surgery and Rheumatology , National Hospital Organization Nagoya 
      Medical Center , Nagoya , Japan.
FAU - Kida, Daihei
AU  - Kida D
AD  - a Orthopaedic Surgery and Rheumatology , National Hospital Organization Nagoya 
      Medical Center , Nagoya , Japan.
FAU - Kaneko, Atsushi
AU  - Kaneko A
AD  - a Orthopaedic Surgery and Rheumatology , National Hospital Organization Nagoya 
      Medical Center , Nagoya , Japan.
LA  - eng
PT  - Journal Article
DEP - 20170731
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Glucocorticoids)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Rheumatoid/*blood/drug therapy/pathology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Glucocorticoids/*therapeutic use
MH  - Humans
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Prednisolone/*therapeutic use
OTO - NOTNLM
OT  - Rheumatoid arthritis
OT  - matrix metalloproteinase-3
OT  - remission
OT  - steroid
EDAT- 2017/08/02 06:00
MHDA- 2018/07/22 06:00
CRDT- 2017/08/01 06:00
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/07/22 06:00 [medline]
PHST- 2017/08/01 06:00 [entrez]
AID - 10.1080/14397595.2017.1354431 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2018 Mar;28(2):242-248. doi: 10.1080/14397595.2017.1354431. Epub 
      2017 Jul 31.