PMID- 28756925
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2352-4146 (Electronic)
IS  - 1995-7645 (Linking)
VI  - 10
IP  - 6
DP  - 2017 Jun
TI  - Intervention effect and mechanism of curcumin in chronic urinary tract infection 
      in rats.
PG  - 594-598
LID - S1995-7645(17)30757-5 [pii]
LID - 10.1016/j.apjtm.2017.06.009 [doi]
AB  - OBJECTIVE: To analyze the invention effect of curcumin on chronic urinary tract 
      infection in rats and explore its possible mechanism of action. METHODS: The 
      experimental animals were randomly divided into three groups, normal, model and 
      curcumin group. Chronic urinary tract infection models were built for model group 
      and curcumin group by injecting coliform fluid into the cavity of bladder. From 
      the first day of modeling, rats in the curcumin group were injected with 
      150 mg/kg curcumin, while rats in normal group and model group were given no 
      other treatment. The treatment lasted for 14 d. The white blood cell counts in 
      blood and urine, bacterial colony count in urine and renal tubular functional 
      indexes of rats in all groups at day 1, 7, and 14 after treatment were detected. 
      Urine beta2-microglobulin (beta2-MG), urinary N-acetyl-beta-D glucosaminidase (NAG) levels 
      were used to detected the inflammatory cytokines in serum after treatment 
      including the contents of IL-6, IL-8, IL-10 and monocyte chemoattractant 
      protein-1 (MCP-1), and real-time PCR was employed to determine the expression of 
      mRNA of toll-like receptor 2 (TLR-2) and TLR-4 in renal tissues and bladder 
      tissues of all groups after treatment. RESULTS: The white blood cell counts at 
      day 1 and 7 after treatment in rats of model group and curcumin group were 
      significantly higher than those of normal group at the same time points, while 
      the white blood cell counts of the curcumin group were significantly lower than 
      those of model group (P < 0.05). The urine white blood cell counts in rats of 
      model group at day 1, 7 and 14 were all significantly higher than those of normal 
      group at the same time points; those in the curcumin group were significantly 
      lower than those of the model group at day 1, 7 and 14 at the same time points 
      (P < 0.05). The bacterial colony counts of urine in rats of model group and 
      curcumin group at day 1, 7 and 14 were all significantly higher than those of 
      normal group at the same time points, while the counts of curcumin group were 
      significantly lower than those of model group at the same time points (P < 0.05). 
      Levels of urine beta2-MG, NAG, IL-6, IL-8, IL-10, MCP-1 and expression of TLR2 mRNA 
      and TLR4 mRNA in renal and bladder tissues in rats of model group were 
      significantly higher than those of the normal group, while these variables of the 
      curcumin group were significantly higher than those of the normal group but lower 
      than those of model group (P < 0.05). CONCLUSIONS: Curcumin can significantly 
      improve the symptoms of chronic urinary tract infections, protect renal tubular 
      function, and also decline inflammatory responses by influencing the expressions 
      of TLR2 mRNA and TLR4 mRNA so as to exert its curative effect on chronic urinary 
      tract infections.
CI  - Copyright (c) 2017 Hainan Medical University. Production and hosting by Elsevier 
      B.V. All rights reserved.
FAU - Xue, Wen-Yong
AU  - Xue WY
AD  - Urinary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 
      050000, Hebei Province, China.
FAU - Qi, Jin-Chun
AU  - Qi JC
AD  - Urinary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 
      050000, Hebei Province, China. Electronic address: 13784386973@163.com.
FAU - Du, Lei
AU  - Du L
AD  - Urinary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 
      050000, Hebei Province, China.
LA  - eng
PT  - Journal Article
DEP - 20170615
PL  - India
TA  - Asian Pac J Trop Med
JT  - Asian Pacific journal of tropical medicine
JID - 101533720
OTO - NOTNLM
OT  - Chronic urinary tract infection
OT  - Curcumin
OT  - Inflammatory response
OT  - Renal tubular function
OT  - TLR-2
OT  - TLR-4
EDAT- 2017/08/02 06:00
MHDA- 2017/08/02 06:01
CRDT- 2017/08/01 06:00
PHST- 2017/03/07 00:00 [received]
PHST- 2017/04/09 00:00 [revised]
PHST- 2017/05/16 00:00 [accepted]
PHST- 2017/08/01 06:00 [entrez]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2017/08/02 06:01 [medline]
AID - S1995-7645(17)30757-5 [pii]
AID - 10.1016/j.apjtm.2017.06.009 [doi]
PST - ppublish
SO  - Asian Pac J Trop Med. 2017 Jun;10(6):594-598. doi: 10.1016/j.apjtm.2017.06.009. 
      Epub 2017 Jun 15.