PMID- 28757089
OWN - NLM
STAT- MEDLINE
DCOM- 20180510
LR  - 20180510
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 245
DP  - 2017 Oct 15
TI  - High-risk patients with mild-moderate left ventricular dysfunction after a 
      previous myocardial infarction. A long-term prognostic data by cardiac magnetic 
      resonance.
PG  - 13-19
LID - S0167-5273(17)31867-3 [pii]
LID - 10.1016/j.ijcard.2017.07.064 [doi]
AB  - BACKGROUND: Few studies have explored prognosis in patients with previous 
      myocardial infarction (MI) with mild-moderate (MM) left ventricular (LV) 
      dysfunction (D). The aim of our study was to investigate whether combining LV 
      parameters obtained by cardiac magnetic resonance (CMR) improves risk 
      stratification of patients with previous MI and MM-LV-D. METHODS: In 418 
      consecutive patients (63.3+/-11.3years old, female 12.9%) with previous MI, we 
      quantified LVEF, volumes and wall motion score index (WMSI) and measured the 
      infarct extent by late gadolinium enhancement (LGE). According to LVEF, patients 
      were considered with normal LVEF (>55%), MM-LV-D (LVEF>30 and </=55%) and severe 
      (S) LV-D (LVEF </=30). RESULTS: During follow-up (median, 39.7months) cardiac 
      events (cardiac death or appropriate intra-cardiac defibrillator shocks) occurred 
      in 17/99 of patients with S-LV-D, in 15/201 with MM-LV-D, and in only 1/118 of 
      those with normal LV-EF. After adjustment for age, an extent of LGE >11.3%, a 
      dilated LV (male >112ml/m(2); female >92ml/m(2)) and a WMSI>1.59 were associated 
      with adverse cardiac events in patients with MM-LV-D. In patients with MM-LV-D, 
      when each of these 3 factors was observed, the prognosis was worse respect to 
      those with 1-2 factors and no factor (p=0.035 and p=0.004, respectively). 
      Prognosis was similar (p=0.61) between MM-LV-D patients with all 3 factors and 
      those with S-LV-dysfunction. CONCLUSIONS: A multiparametric CMR approach, which 
      includes LGE, dilated LV and WMSI, permits to identify post MI patients with 
      MM-LV-D with a risk of cardiac events similar to those with S-LV-D. Further 
      multicenter studies are needed to confirm our data.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Di Bella, Gianluca
AU  - Di Bella G
AD  - CNR Institute of Clinical Physiology, Pisa, Italy; Clinical and Experimental 
      Department of Medicine and Pharmacology, University of Messina, Messina, Italy. 
      Electronic address: gianluca.dibella@tiscali.it.
FAU - Pizzino, Fausto
AU  - Pizzino F
AD  - Fondazione Toscana G. Monasterio, CNR, Regione Toscana, Pisa, Italy; Clinical and 
      Experimental Department of Medicine and Pharmacology, University of Messina, 
      Messina, Italy.
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
AD  - Clinical and Experimental Department of Medicine and Pharmacology, University of 
      Messina, Messina, Italy.
FAU - Piaggi, Paolo
AU  - Piaggi P
AD  - Department of Clinical and Experimental Medicine, Section of Endocrinology, 
      University of Pisa, Pisa, Italy.
FAU - Venuti, Giuseppe
AU  - Venuti G
AD  - Clinical and Experimental Department of Medicine and Pharmacology, University of 
      Messina, Messina, Italy.
FAU - Carerj, Scipione
AU  - Carerj S
AD  - Clinical and Experimental Department of Medicine and Pharmacology, University of 
      Messina, Messina, Italy.
FAU - Pingitore, Alessandro
AU  - Pingitore A
AD  - CNR Institute of Clinical Physiology, Pisa, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170720
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*trends
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnostic imaging/*epidemiology/physiopathology
MH  - Prognosis
MH  - Risk Factors
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/*epidemiology/physiopathology
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Left ventricular volumes
OT  - Previous myocardial infarction
OT  - Scar tissue
OT  - Wall motion abnormalities
EDAT- 2017/08/02 06:00
MHDA- 2018/05/11 06:00
CRDT- 2017/08/01 06:00
PHST- 2017/03/24 00:00 [received]
PHST- 2017/07/15 00:00 [revised]
PHST- 2017/07/18 00:00 [accepted]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/05/11 06:00 [medline]
PHST- 2017/08/01 06:00 [entrez]
AID - S0167-5273(17)31867-3 [pii]
AID - 10.1016/j.ijcard.2017.07.064 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Oct 15;245:13-19. doi: 10.1016/j.ijcard.2017.07.064. Epub 
      2017 Jul 20.