PMID- 28757148
OWN - NLM
STAT- MEDLINE
DCOM- 20180501
LR  - 20181202
IS  - 1532-8384 (Electronic)
IS  - 0010-440X (Print)
IS  - 0010-440X (Linking)
VI  - 79
DP  - 2017 Nov
TI  - Transdiagnostic psychiatric disorder risk associated with early age of menarche: 
      A latent modeling approach.
PG  - 70-79
LID - S0010-440X(17)30070-6 [pii]
LID - 10.1016/j.comppsych.2017.06.010 [doi]
AB  - BACKGROUND: Earlier age of pubertal maturation in females is associated with 
      increased risk for mental health problems in adolescence, compared with on-time 
      or later maturation. However, most investigations of pubertal timing and mental 
      health consider risk for individual disorders and fail to account for 
      comorbidity. A latent-modeling approach using a large, nationally representative 
      sample could better explain the transdiagnostic nature of the consequences of 
      early-onset puberty. METHODS: Data on age of menarche and mental disorders were 
      drawn from a population-representative sample of adolescents (n=4925), ages 
      13-17. Confirmatory factor analysis was used to fit four latent disorder 
      categories: distress, eating, and externalizing, and fear disorders. Timing of 
      menarche included those with earlier (age</=10, age 11) and later age of onset (age 
      13, 14+), relative to those with average timing of menarche (age 12). 
      Associations between timing of menarche and latent disorders were estimated in a 
      structural equation model (SEM), adjusted for age, income, race, parent marital 
      status, BMI, and childhood adversity. RESULTS: The measurement model evidenced 
      acceptable fit (CFI=0.91; RMSEA=0.02). Onset of menarche before age 11 was 
      significantly associated with distress disorders (coefficient=0.096; p<0.0001), 
      fear disorders (coefficient=0.09; p<0.0001), and externalizing disorders 
      (coefficient=0.039; p=0.049) as compared to on-time or late menarche. No residual 
      associations of early menarche with individual disorders over and above the 
      latent disorders were observed. CONCLUSION: The latent modeling approach 
      illuminated meaningful transdiagnostic psychiatric associations with early timing 
      of menarche. Biological processes initiated at puberty can influence cognitive 
      and affective processes as well as social relationships for adolescents. Under 
      developmentally normative conditions, these changes may be adaptive. However, for 
      those out of sync with their peers, researchers and clinicians should recognize 
      the potential for these processes to influence liability to a broad array of 
      psychopathological consequences in adolescence.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Platt, Jonathan M
AU  - Platt JM
AD  - Columbia University, United States. Electronic address: 
      jmp2198@cumc.columbia.edu.
FAU - Colich, Natalie L
AU  - Colich NL
AD  - Stanford University, United States.
FAU - McLaughlin, Katie A
AU  - McLaughlin KA
AD  - University of Washington, United States.
FAU - Gary, Dahsan
AU  - Gary D
AD  - Columbia University, United States.
FAU - Keyes, Katherine M
AU  - Keyes KM
AD  - Columbia University, United States.
LA  - eng
GR  - R01 MH103291/MH/NIMH NIH HHS/United States
GR  - R01 MH106482/MH/NIMH NIH HHS/United States
GR  - T32 MH013043/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20170706
PL  - United States
TA  - Compr Psychiatry
JT  - Comprehensive psychiatry
JID - 0372612
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Menarche/physiology/*psychology
MH  - Mental Disorders/*diagnosis/*psychology
MH  - *Models, Psychological
MH  - Risk Factors
MH  - Sexual Maturation/physiology
PMC - PMC5643227
MID - NIHMS890853
COIS- Conflicts of interest: None.
EDAT- 2017/08/02 06:00
MHDA- 2018/05/02 06:00
PMCR- 2018/11/01
CRDT- 2017/08/01 06:00
PHST- 2017/02/03 00:00 [received]
PHST- 2017/05/04 00:00 [revised]
PHST- 2017/06/22 00:00 [accepted]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/05/02 06:00 [medline]
PHST- 2017/08/01 06:00 [entrez]
PHST- 2018/11/01 00:00 [pmc-release]
AID - S0010-440X(17)30070-6 [pii]
AID - 10.1016/j.comppsych.2017.06.010 [doi]
PST - ppublish
SO  - Compr Psychiatry. 2017 Nov;79:70-79. doi: 10.1016/j.comppsych.2017.06.010. Epub 
      2017 Jul 6.