PMID- 28757197
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20180717
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 46
IP  - 1
DP  - 2018 Jan-Feb
TI  - Correlation between serum vitamin D status and immunological changes in children 
      affected by gastrointestinal food allergy.
PG  - 39-44
LID - S0301-0546(17)30072-1 [pii]
LID - 10.1016/j.aller.2017.03.005 [doi]
AB  - BACKGROUND: Low vitamin D status is linked to increased incidence of food allergy 
      and intestinal inflammation. Whether vitamin D status is associated with 
      immunological changes in children with gastrointestinal food allergy (GFA) 
      remains unclear. METHODS: Forty-nine GFA children (aged 2-11 years old) were 
      enrolled in this study. Serum 25-hydroxyvitamin D (25OHD) level, total 
      immunoglobulin E (IgE), specific IgE against allergens, circulating regulatory T 
      lymphocytes (Tregs), and blood eosinophil numbers were measured. RESULTS: Levels 
      of serum 25OHD in the GFA children ranged 35.5-156.4nmol/L, with a mean value 
      similar to that of the healthy controls. Compared to those with normal 25OHD 
      (>/=75nmol/L), GFA children with low 25OHD (<75nmol/L) had increased total IgE (84% 
      vs. 54%, P<0.05), persistent blood eosinophilia (56% vs. 25%, P<0.05), and 
      delayed resolution of symptoms after food allergen elimination (odds ratio 3.51, 
      95% CI 1.00-12.36, P<0.05). Among the GFA children with elevated total IgE, those 
      with low 25OHD had lower circulatory Tregs (8.79+/-2.4% vs. 10.21+/-1.37%, P<0.05), 
      higher total IgE (1197.5+/-1209.8 vs. 418.5+/-304.6kU/L, P<0.05), and persistent 
      eosinophilia (0.61+/-0.52 vs. 0.31+/-0.15x10(9)cells/L, P<0.05) compared to those 
      with normal 25OHD. In addition, serum 25OHD concentrations inversely correlated 
      with total IgE (R=-0.434, P<0.05), and positively with Treg population (R=0.356, 
      P<0.05). CONCLUSION: Low serum vitamin D status correlates with stronger allergic 
      immune response in GFA children.
CI  - Copyright (c) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights 
      reserved.
FAU - Guo, H
AU  - Guo H
AD  - Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing 
      Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China.
FAU - Zheng, Y
AU  - Zheng Y
AD  - Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing 
      Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China.
FAU - Cai, X
AU  - Cai X
AD  - Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing 
      Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China.
FAU - Yang, H
AU  - Yang H
AD  - Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing 
      Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China.
FAU - Zhang, Y
AU  - Zhang Y
AD  - Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing 
      Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China.
FAU - Hao, L
AU  - Hao L
AD  - Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing 
      Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China.
FAU - Jin, Y
AU  - Jin Y
AD  - Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing 
      Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China.
FAU - Yang, G
AU  - Yang G
AD  - Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing 
      Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China. Electronic 
      address: gyangnj@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20170727
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Allergens)
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Child
MH  - Child, Preschool
MH  - Eosinophils/*immunology
MH  - Female
MH  - Food Hypersensitivity/*immunology
MH  - Gastrointestinal Tract
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Vitamin D/*blood
OTO - NOTNLM
OT  - Eosinophilia
OT  - Gastrointestinal food allergy
OT  - Regulatory T cells
OT  - Total immunoglobulin E
OT  - Vitamin D
EDAT- 2017/08/02 06:00
MHDA- 2018/07/18 06:00
CRDT- 2017/08/01 06:00
PHST- 2017/01/09 00:00 [received]
PHST- 2017/03/19 00:00 [revised]
PHST- 2017/03/30 00:00 [accepted]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2017/08/01 06:00 [entrez]
AID - S0301-0546(17)30072-1 [pii]
AID - 10.1016/j.aller.2017.03.005 [doi]
PST - ppublish
SO  - Allergol Immunopathol (Madr). 2018 Jan-Feb;46(1):39-44. doi: 
      10.1016/j.aller.2017.03.005. Epub 2017 Jul 27.