PMID- 28757245
OWN - NLM
STAT- MEDLINE
DCOM- 20180605
LR  - 20180605
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 360
DP  - 2017 Sep 30
TI  - Long-term voluntary exercise prevents post-weaning social isolation-induced 
      cognitive impairment in rats.
PG  - 1-8
LID - S0306-4522(17)30522-5 [pii]
LID - 10.1016/j.neuroscience.2017.07.045 [doi]
AB  - This study aimed to determine the effect of exercise on locomotion, 
      anxiety-related behavior, learning, and memory in socially isolated post-weaning 
      rats, as well as the correlation between exercise and the concentration of 
      brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the 
      hippocampus. Rats were randomly assigned to three groups: the control group; the 
      social isolation group; the social isolation plus exercise (SIE) group. Social 
      isolation conditions, with or without exercise were maintained for 90d, and then 
      multiple behavioral tests, including the open-field test, elevated plus maze 
      test, and Morris water maze (MWM) test were administered. Following behavioral 
      assessment, hippocampal tissue samples were obtained for measurement of BDNF and 
      NGF. There wasn't a significant difference in locomotor activity between the 
      groups (P>0.05). Anxiety scores were higher in the socially isolated group 
      (P<0.05) than in the SIE group (P<0.05). According to the probe trial session of 
      the MWM test results, exercise training improved platform crossings' number in 
      the socially isolated rats (P<0.05). Exercise training ameliorated social 
      isolation-induced reduction in hippocampal BDNF and NGF content (P<0.05). These 
      findings suggest that exercise training improves cognitive functions via 
      increasing hippocampal BDNF and NGF concentrations in socially isolated 
      post-weaning rats.
CI  - Copyright (c) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Okudan, Nilsel
AU  - Okudan N
AD  - Selcuk University, School of Medicine, Department of Physiology, Konya, Turkey.
FAU - Belviranli, Muaz
AU  - Belviranli M
AD  - Selcuk University, School of Medicine, Department of Physiology, Konya, Turkey. 
      Electronic address: mbelviranli@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20170728
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/*physiology
MH  - Cognitive Dysfunction/metabolism/*physiopathology
MH  - Hippocampus/physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/*physiology
MH  - Physical Conditioning, Animal
MH  - Rats, Wistar
MH  - Social Isolation/*psychology
MH  - Time
MH  - Weaning
OTO - NOTNLM
OT  - BDNF
OT  - NGF
OT  - anxiety
OT  - cognitive function
OT  - exercise
OT  - social isolation
EDAT- 2017/08/02 06:00
MHDA- 2018/06/06 06:00
CRDT- 2017/08/01 06:00
PHST- 2016/12/05 00:00 [received]
PHST- 2017/07/18 00:00 [revised]
PHST- 2017/07/19 00:00 [accepted]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/06/06 06:00 [medline]
PHST- 2017/08/01 06:00 [entrez]
AID - S0306-4522(17)30522-5 [pii]
AID - 10.1016/j.neuroscience.2017.07.045 [doi]
PST - ppublish
SO  - Neuroscience. 2017 Sep 30;360:1-8. doi: 10.1016/j.neuroscience.2017.07.045. Epub 
      2017 Jul 28.