PMID- 28757581 OWN - NLM STAT- MEDLINE DCOM- 20180524 LR - 20240324 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 9 IP - 8 DP - 2017 Jul 25 TI - Identification of Urinary Polyphenol Metabolite Patterns Associated with Polyphenol-Rich Food Intake in Adults from Four European Countries. LID - 10.3390/nu9080796 [doi] LID - 796 AB - We identified urinary polyphenol metabolite patterns by a novel algorithm that combines dimension reduction and variable selection methods to explain polyphenol-rich food intake, and compared their respective performance with that of single biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 475 adults from four European countries (Germany, France, Italy, and Greece). Dietary intakes were assessed with 24-h dietary recalls (24-HDR) and dietary questionnaires (DQ). Thirty-four polyphenols were measured by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS-MS) in 24-h urine. Reduced rank regression-based variable importance in projection (RRR-VIP) and least absolute shrinkage and selection operator (LASSO) methods were used to select polyphenol metabolites. Reduced rank regression (RRR) was then used to identify patterns in these metabolites, maximizing the explained variability in intake of pre-selected polyphenol-rich foods. The performance of RRR models was evaluated using internal cross-validation to control for over-optimistic findings from over-fitting. High performance was observed for explaining recent intake (24-HDR) of red wine (r = 0.65; AUC = 89.1%), coffee (r = 0.51; AUC = 89.1%), and olives (r = 0.35; AUC = 82.2%). These metabolite patterns performed better or equally well compared to single polyphenol biomarkers. Neither metabolite patterns nor single biomarkers performed well in explaining habitual intake (as reported in the DQ) of polyphenol-rich foods. This proposed strategy of biomarker pattern identification has the potential of expanding the currently still limited list of available dietary intake biomarkers. FAU - Noh, Hwayoung AU - Noh H AD - Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France. NohH@fellows.iarc.fr. FAU - Freisling, Heinz AU - Freisling H AD - Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France. FreislingH@iarc.fr. FAU - Assi, Nada AU - Assi N AD - Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France. AssiN@students.iarc.fr. FAU - Zamora-Ros, Raul AU - Zamora-Ros R AD - Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France. RaulZamoraros@gmail.com. AD - Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Spain. RaulZamoraros@gmail.com. FAU - Achaintre, David AU - Achaintre D AD - Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France. AchaintreD@iarc.fr. FAU - Affret, Aurelie AU - Affret A AD - Universite Paris-Saclay, Universite Paris-Sud, Universite de Versailles Saint-Quentin-en-Yvelines (UVSQ), Le Centre de recherche en Epidemiologie et Sante des Population (CESP), Institut National de la Sante et de la Recherche Medicale (INSERM), 94800 Villejuif, France. Aurelie.AFFRET@gustaveroussy.fr. AD - Gustave Roussy, 94800 Villejuif, France. Aurelie.AFFRET@gustaveroussy.fr. FAU - Mancini, Francesca AU - Mancini F AD - Universite Paris-Saclay, Universite Paris-Sud, Universite de Versailles Saint-Quentin-en-Yvelines (UVSQ), Le Centre de recherche en Epidemiologie et Sante des Population (CESP), Institut National de la Sante et de la Recherche Medicale (INSERM), 94800 Villejuif, France. Francesca.Mancini@gustaveroussy.fr. AD - Gustave Roussy, 94800 Villejuif, France. Francesca.Mancini@gustaveroussy.fr. FAU - Boutron-Ruault, Marie-Christine AU - Boutron-Ruault MC AD - Universite Paris-Saclay, Universite Paris-Sud, Universite de Versailles Saint-Quentin-en-Yvelines (UVSQ), Le Centre de recherche en Epidemiologie et Sante des Population (CESP), Institut National de la Sante et de la Recherche Medicale (INSERM), 94800 Villejuif, France. Marie-christine.BOUTRON@gustaveroussy.fr. AD - Gustave Roussy, 94800 Villejuif, France. Marie-christine.BOUTRON@gustaveroussy.fr. FAU - Flogel, Anna AU - Flogel A AD - Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrucke, 14558 Nuthetal, Germany. Anna.Floegel@dife.de. FAU - Boeing, Heiner AU - Boeing H AD - Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrucke, 14558 Nuthetal, Germany. boeing@dife.de. FAU - Kuhn, Tilman AU - Kuhn T AD - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. T.Kuehn@Dkfz-Heidelberg.de. FAU - Schubel, Ruth AU - Schubel R AD - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. R.Schuebel@dkfz-heidelberg.de. FAU - Trichopoulou, Antonia AU - Trichopoulou A AD - Hellenic Health Foundation, 115 27 Athens, Greece. atrichopoulou@hhf-greece.gr. AD - WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 157 72 Athens, Greece. atrichopoulou@hhf-greece.gr. FAU - Naska, Androniki AU - Naska A AD - Hellenic Health Foundation, 115 27 Athens, Greece. anaska@hhf-greece.gr. AD - WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 157 72 Athens, Greece. anaska@hhf-greece.gr. FAU - Kritikou, Maria AU - Kritikou M AD - Hellenic Health Foundation, 115 27 Athens, Greece. maria.kritikou@hhf-greece.gr. FAU - Palli, Domenico AU - Palli D AD - Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), 50139 Florence, Italy. d.palli@ispo.toscana.it. FAU - Pala, Valeria AU - Pala V AD - Epidemiology and Prevention Unit, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy. Valeria.Pala@istitutotumori.mi.it. FAU - Tumino, Rosario AU - Tumino R AD - Cancer Registry and Histopathology Unit, "Civic-M.P.Arezzo" Hospital, ASP Ragusa, 97100 Ragusa, Italy. rosario.tumino@asp.rg.it. FAU - Ricceri, Fulvio AU - Ricceri F AD - Unit of Epidemiology, Regional Health Service ASL TO3, 10095 Grugliasco (TO), Italy. fulvio.ricceri@unito.it. AD - Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, 10124 Turin, Italy. fulvio.ricceri@unito.it. FAU - Santucci de Magistris, Maria AU - Santucci de Magistris M AD - Azienda Ospedaliera Universitaria (AOU) Federico II, 80131 Naples, Italy. masantuc@unina.it. FAU - Cross, Amanda AU - Cross A AD - Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK. amanda.cross@imperial.ac.uk. FAU - Slimani, Nadia AU - Slimani N AD - Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France. SlimaniN@iarc.fr. FAU - Scalbert, Augustin AU - Scalbert A AD - Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France. ScalbertA@iarc.fr. FAU - Ferrari, Pietro AU - Ferrari P AD - Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France. FerrariP@iarc.fr. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article PT - Multicenter Study DEP - 20170725 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (Coffee) RN - 0 (Polyphenols) SB - IM MH - Adult MH - Aged MH - Biomarkers/urine MH - Body Mass Index MH - Coffee/chemistry MH - *Diet MH - Europe MH - Exercise MH - Female MH - Humans MH - Male MH - Mental Recall MH - Middle Aged MH - Nutrition Assessment MH - Olea/chemistry MH - Polyphenols/*administration & dosage/*urine MH - Prospective Studies MH - Surveys and Questionnaires MH - White People MH - Wine/analysis PMC - PMC5579590 OTO - NOTNLM OT - EPIC OT - dietary biomarker patterns OT - polyphenol metabolites OT - polyphenol-rich food OT - reduced rank regression (RRR) COIS- The authors declare no conflict of interest. EDAT- 2017/08/02 06:00 MHDA- 2018/05/25 06:00 PMCR- 2017/08/01 CRDT- 2017/08/01 06:00 PHST- 2017/06/30 00:00 [received] PHST- 2017/07/18 00:00 [revised] PHST- 2017/07/18 00:00 [accepted] PHST- 2017/08/01 06:00 [entrez] PHST- 2017/08/02 06:00 [pubmed] PHST- 2018/05/25 06:00 [medline] PHST- 2017/08/01 00:00 [pmc-release] AID - nu9080796 [pii] AID - nutrients-09-00796 [pii] AID - 10.3390/nu9080796 [doi] PST - epublish SO - Nutrients. 2017 Jul 25;9(8):796. doi: 10.3390/nu9080796.