PMID- 28757723
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1016-3190 (Print)
IS  - 2223-8956 (Electronic)
VI  - 28
IP  - 2
DP  - 2016 Apr-Jun
TI  - Deduced probable HLA-C*07:359-associated human leukocyte antigen haplotypes found 
      by case analysis of Taiwanese unrelated bone marrow hematopoietic stem cell 
      donors.
PG  - 59-62
LID - 10.1016/j.tcmj.2016.04.004 [doi]
AB  - OBJECTIVES: HLA-C*07:359 is a low-incidence allele in the human leukocyte antigen 
      (HLA)-C locus. The objective of this study is to report the ethnicity and 
      haplotypes of HLA-C*07:359 that were found during an analysis of Taiwanese 
      unrelated bone marrow hematopoietic stem cell donors. MATERIALS AND METHODS: A 
      sequence-based typing method was employed to confirm low-incidence al-leles. 
      Polymerase chain reaction was performed to amplify exon 2 and exon 3 of the 
      HLA-A, HLA-B, and HLA-C loci, as well as exon 2 of the HLA-DRB1 locus, using 
      group-specific primer sets. The amplicons were sequenced in both directions using 
      BigDye Terminator Cycle Sequencing Ready Reaction kits, according to the 
      manufacturer's protocols. The potential unrelated bone marrow stem cell donors 
      investigated here are individuals with Taiwanese ethnicity who are participating 
      in the Tzu Chi Bone Marrow Donor Registry. RESULTS: The DNA sequence of C*07:359 
      is identical to that of C*07:02:01:01 in exons 2, 3, and 4 except at residue 862, 
      where the G of C*07:02:01:01 is substituted by the A of C*07:359. The nucleotide 
      exchange leads to an amino acid replacement at codon 264, where the glutamic acid 
      of C*07:02:01:01 is replaced by the lysine of C*07:359. We deduced a probable 
      HLA-B and HLA-C haplotype that is associated with C*07:359 in Taiwanese, namely 
      B*39-C*07:359. CONCLUSION: Information on the ethnicity of the C*07:359 allele 
      and its deduced probable HLA haplotypes that are associated with the 
      low-incidence C*07:359 allele reported here are of value to HLA testing 
      laboratories for reference purposes. In addition, they can be used by stem cell 
      transplantation donor search coordinators to determine a strategy for finding 
      compatible donors using unrelated bone marrow donor registries when patients 
      carry this uncommon HLA allele.
FAU - Yang, Kuo-Liang
AU  - Yang KL
AD  - Laboratory of Immunogenetics, Tzu Chi Cord Blood Bank and Buddhist Tzu Chi Marrow 
      Donor Registry, Buddhist Tzu Chi Stem Cells Centre, Hualien Tzu Chi Hospital, 
      Hualien, Taiwan.
AD  - Department of Laboratory Medicine, Buddhist Tzu Chi University, Hualien, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20160527
PL  - China (Republic : 1949- )
TA  - Ci Ji Yi Xue Za Zhi
JT  - Ci ji yi xue za zhi = Tzu-chi medical journal
JID - 9514171
PMC - PMC5442894
OTO - NOTNLM
OT  - Haplotype
OT  - Hematopoietic stem cell
OT  - Human leukocyte antigen
OT  - Sequence-based typing
OT  - Transplantation
COIS- Conflict of interest: none.
EDAT- 2016/04/01 00:00
MHDA- 2016/04/01 00:01
PMCR- 2016/04/01
CRDT- 2017/08/01 06:00
PHST- 2016/02/24 00:00 [received]
PHST- 2016/03/14 00:00 [revised]
PHST- 2016/03/18 00:00 [accepted]
PHST- 2017/08/01 06:00 [entrez]
PHST- 2016/04/01 00:00 [pubmed]
PHST- 2016/04/01 00:01 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - TCMJ-28-59 [pii]
AID - 10.1016/j.tcmj.2016.04.004 [doi]
PST - ppublish
SO  - Ci Ji Yi Xue Za Zhi. 2016 Apr-Jun;28(2):59-62. doi: 10.1016/j.tcmj.2016.04.004. 
      Epub 2016 May 27.