PMID- 28757776
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 1016-3190 (Print)
IS  - 2223-8956 (Electronic)
VI  - 29
IP  - 2
DP  - 2017 Apr-Jun
TI  - Leptin is an independent marker of metabolic syndrome in elderly adults with type 
      2 diabetes.
PG  - 109-114
LID - 10.4103/tcmj.tcmj_31_17 [doi]
AB  - OBJECTIVE: It is well established that patients with metabolic syndrome (MetS) 
      demonstrate elevated levels of serum leptin. The aim of this study is to identify 
      fasting serum leptin as an independent marker of MetS in geriatric diabetic 
      patients. MATERIALS AND METHODS: Sixty-four patients over 65 years old with type 
      2 diabetic mellitus (T2DM) were assessed for MetS based on the diagnostic 
      criteria of the International Diabetes Federation. Fasting blood samples 
      including serum leptin concentrations were obtained from the participants. Leptin 
      levels were determined using a commercial enzyme immunoassay. RESULTS: Forty-five 
      (70.3%) of the 64 geriatric T2DM patients enrolled in this study were found to 
      have MetS. This group of participants compared with those in the non-MetS group 
      had higher serum levels of leptin (P = 0.004), triglycerides (P = 0.005), fasting 
      glucose (P = 0.049), glycated hemoglobin (P = 0.016), white blood cells (P = 
      0.003), C-reactive protein (CRP, P = 0.028), insulin (P < 0.001), higher 
      homeostatic model assessment insulin resistance values (HOMA1-IR and HOMA2-IR, 
      both P < 0.001), a higher body weight (P = 0.024), body mass index (P < 0.001), 
      body fat mass (P < 0.001), waist circumference (P < 0.001), systolic blood 
      pressure (BP) (P < 0.001), diastolic BP (P < 0.001), percentage of women (P = 
      0.011), prevalence of hypertension (P = 0.042), and a lower level of serum 
      high-density lipoprotein cholesterol (P = 0.001). Univariate linear analysis of 
      the clinical variables associated with the fasting serum leptin level revealed 
      that height (P = 0.020) had a negative correlation, while body fat mass (P < 
      0.001) and logarithmically transformed CRP (log-CRP, P < 0.001) had positive 
      correlations with serum leptin levels. Multivariate forward step-wise linear 
      regression analysis of the variables significantly associated with fasting serum 
      leptin levels showed that body fat mass (P < 0.001) and log-CRP (P = 0.001) were 
      independent predictors of these values. CONCLUSION: Serum leptin is positively 
      correlated with MetS. It serves as an independent marker of MetS in elderly 
      patients with T2DM.
FAU - Tseng, Pei-Wei
AU  - Tseng PW
AD  - School of Medicine, Tzu Chi University, Hualien, Taiwan.
FAU - Wu, Du-An
AU  - Wu DA
AD  - School of Medicine, Tzu Chi University, Hualien, Taiwan.
AD  - Division of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, 
      Hualien, Taiwan.
FAU - Hou, Jia-Sian
AU  - Hou JS
AD  - Department of Nursing, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
FAU - Hsu, Bang-Gee
AU  - Hsu BG
AD  - School of Medicine, Tzu Chi University, Hualien, Taiwan.
AD  - Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Ci Ji Yi Xue Za Zhi
JT  - Ci ji yi xue za zhi = Tzu-chi medical journal
JID - 9514171
PMC - PMC5509196
OTO - NOTNLM
OT  - Elderly
OT  - Leptin
OT  - Metabolic syndrome
OT  - Type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2017/08/02 06:00
MHDA- 2017/08/02 06:01
PMCR- 2017/04/01
CRDT- 2017/08/01 06:00
PHST- 2017/08/01 06:00 [entrez]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2017/08/02 06:01 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - TCMJ-29-109 [pii]
AID - 10.4103/tcmj.tcmj_31_17 [doi]
PST - ppublish
SO  - Ci Ji Yi Xue Za Zhi. 2017 Apr-Jun;29(2):109-114. doi: 10.4103/tcmj.tcmj_31_17.