PMID- 28758129
OWN - NLM
STAT- MEDLINE
DCOM- 20180501
LR  - 20220410
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2017
DP  - 2017
TI  - The Association of Haptoglobin Gene Variants and Retinopathy in Type 2 Diabetic 
      Patients: A Meta-Analysis.
PG  - 2195059
LID - 10.1155/2017/2195059 [doi]
LID - 2195059
AB  - AIMS/INTRODUCTION: To collectively evaluate the association between haptoglobin 
      (Hp) gene variants and diabetic retinopathy (DR) in patients with type 2 diabetes 
      mellitus (T2DM). METHODS: A comprehensive literature review was performed for 
      eligible studies. After inclusion and exclusion selection as well as quality 
      assessment, those studies meeting quality standards were included. In this study, 
      diabetic patients with retinopathy were selected as the case group and those ones 
      without DR were treated as the control group. The recessive model, allele model, 
      additive model, heterozygote model, and homozygote model were utilized to 
      investigate the association of three Hp gene variants and DR. Subgroup analysis 
      on different severity of DR including nonproliferative diabetic retinopathy 
      (NPDR) and proliferative diabetic retinopathy (PDR) was also conducted. RESULTS: 
      Six trials from different regions were finally included. A total of 1145 subjects 
      containing 564 T2DM patients with retinopathy were included. The recessive model, 
      allele model, additive model, and homozygote model results showed that Hp gene 
      variants were not associated with DR, NPDR, and PDR. However, the heterozygote 
      model indicated the association of Hp gene variants with DR. CONCLUSIONS: No 
      association was found between the Hp gene variants and PDR and NPDR. More studies 
      are required to verify these findings.
FAU - Wu, Huiqun
AU  - Wu H
AUID- ORCID: 0000-0001-5837-6199
AD  - Department of Medical Informatics, Medical School of Nantong University, Nantong 
      226001, China.
AD  - Department of Biomedical Engineering, University of Southern California, Los 
      Angeles, CA 90089, USA.
FAU - Wu, Huan
AU  - Wu H
AUID- ORCID: 0000-0001-7810-7121
AD  - Department of Medical Informatics, Medical School of Nantong University, Nantong 
      226001, China.
FAU - Shi, Lili
AU  - Shi L
AD  - Department of Medical Informatics, Medical School of Nantong University, Nantong 
      226001, China.
FAU - Yuan, Xinlu
AU  - Yuan X
AD  - Department of Endocrinology, Affiliated Hospital of Nantong University, Nantong 
      226001, China.
FAU - Yin, Ying
AU  - Yin Y
AUID- ORCID: 0000-0001-6553-1644
AD  - Department of Medical Informatics, Medical School of Nantong University, Nantong 
      226001, China.
FAU - Yuan, Mingjie
AU  - Yuan M
AUID- ORCID: 0000-0001-7146-6498
AD  - Department of Medical Informatics, Medical School of Nantong University, Nantong 
      226001, China.
FAU - Zhou, Yushan
AU  - Zhou Y
AUID- ORCID: 0000-0002-2370-4196
AD  - Department of Medical Informatics, Medical School of Nantong University, Nantong 
      226001, China.
FAU - Hu, Qianwen
AU  - Hu Q
AD  - Department of Medical Informatics, Medical School of Nantong University, Nantong 
      226001, China.
FAU - Jiang, Kui
AU  - Jiang K
AUID- ORCID: 0000-0002-0327-7385
AD  - Department of Medical Informatics, Medical School of Nantong University, Nantong 
      226001, China.
FAU - Dong, Jiancheng
AU  - Dong J
AD  - Department of Medical Informatics, Medical School of Nantong University, Nantong 
      226001, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20170703
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (HP protein, human)
RN  - 0 (Haptoglobins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/diagnosis/epidemiology/*genetics
MH  - Diabetic Retinopathy/diagnosis/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Haptoglobins/*genetics
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Phenotype
MH  - Risk Factors
PMC - PMC5512055
EDAT- 2017/08/02 06:00
MHDA- 2018/05/02 06:00
PMCR- 2017/07/03
CRDT- 2017/08/01 06:00
PHST- 2017/02/25 00:00 [received]
PHST- 2017/05/23 00:00 [accepted]
PHST- 2017/08/01 06:00 [entrez]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/05/02 06:00 [medline]
PHST- 2017/07/03 00:00 [pmc-release]
AID - 10.1155/2017/2195059 [doi]
PST - ppublish
SO  - J Diabetes Res. 2017;2017:2195059. doi: 10.1155/2017/2195059. Epub 2017 Jul 3.