PMID- 2875893
OWN - NLM
STAT- MEDLINE
DCOM- 19861117
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 128
IP  - 1-2
DP  - 1986 Aug 22
TI  - The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 
      3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain.
PG  - 41-8
AB  - The effects of two amphetamine-like designer drugs, 3,4-methylenedioxyamphetamine 
      (MDA) and 3,4-methylenedioxymethamphetamine (MDMA), on dopaminergic and 
      serotonergic systems in the rat brain were investigated and compared to those of 
      methamphetamine (METH). Like METH, single or multiple 10 mg/kg doses of either 
      drug caused marked reductions in both tryptophan hydroxylase (TPH) activity and 
      concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid, in 
      several serotonergic nerve terminal regions. In all regions examined, the 
      reduction in 5-HT content corresponded to the depression of TPH activity. Unlike 
      multiple METH administrations, which induced pronounced deficits in dopaminergic 
      neuronal markers, repeated doses of MDA or MDMA did not alter striatal tyrosine 
      hydroxylase (TH) activities or reduce striatal dopamine concentrations. A single 
      dose of MDA or MDMA significantly elevated striatal dopamine content; however, 
      after repeated drug administrations dopamine concentrations were comparable to 
      control values. At this time, striatal levels of homovanillic acid were 
      significantly elevated suggesting that both drugs influence dopamine turnover. 
      The effects of MDA or MDMA administration in the rat brain are reminiscent of 
      those elicited by p-chloroamphetamine, a presumed serotonergic neurotoxin.
FAU - Stone, D M
AU  - Stone DM
FAU - Stahl, D C
AU  - Stahl DC
FAU - Hanson, G R
AU  - Hanson GR
FAU - Gibb, J W
AU  - Gibb JW
LA  - eng
GR  - DA 00869/DA/NIDA NIH HHS/United States
GR  - GM 07579/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 0 (Biogenic Amines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/analysis
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Biogenic Amines/*metabolism
MH  - Brain/*drug effects
MH  - Brain Chemistry/drug effects
MH  - Dopamine/analysis
MH  - Homovanillic Acid/analysis
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/analysis
MH  - Tyrosine 3-Monooxygenase/metabolism
EDAT- 1986/08/22 00:00
MHDA- 1986/08/22 00:01
CRDT- 1986/08/22 00:00
PHST- 1986/08/22 00:00 [pubmed]
PHST- 1986/08/22 00:01 [medline]
PHST- 1986/08/22 00:00 [entrez]
AID - 0014-2999(86)90555-8 [pii]
AID - 10.1016/0014-2999(86)90555-8 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1986 Aug 22;128(1-2):41-8. doi: 10.1016/0014-2999(86)90555-8.