PMID- 28759269
OWN - NLM
STAT- MEDLINE
DCOM- 20180724
LR  - 20180903
IS  - 1525-6073 (Electronic)
IS  - 0742-0528 (Linking)
VI  - 34
IP  - 8
DP  - 2017
TI  - Disrupted circadian rhythms of body temperature, heart rate and fasting blood 
      glucose in prediabetes and type 2 diabetes mellitus.
PG  - 1136-1148
LID - 10.1080/07420528.2017.1347670 [doi]
AB  - We report a progressive disruption of 24-h rhythms in fasting blood glucose 
      (FBG), body temperature (BT) and heart rate (HR) associated with metabolic 
      dysfunction and the development of prediabetes (PD) and type 2 diabetes mellitus 
      (T2DM) in overweight middle-aged (40-69 years old) humans. Increasing BT and HR 
      mean values and declining 24-h BT and HR amplitudes accompany adverse changes in 
      metabolic state. Increased nocturnal BT and a phase delay of the 24-h BT rhythm, 
      deviant 24-h HR profile and a phase advance of the 24-h HR and FBG rhythms are 
      early signs of the PD metabolic state. In T2DM, the 24-h FBG rhythm is no longer 
      detectable, and the 24-h amplitudes of BT and HR are greatly diminished. In 
      addition, lepton and creatinine values were lowered in T2DM. Moreover, positive 
      correlations between FBG and body mass index, BMI, and negative correlations 
      between the 24-h amplitude of FBG and BMI indicate that overweight is an 
      additional factor causing disruption of the circadian rhythms. Further studies on 
      circadian disruption as a consequence of metabolic dysfunction are necessary. The 
      quantitative analysis of changing circadian BT and HR rhythms may provide 
      prognostic markers of T2DM and therapeutic targets for its prevention and 
      correction.
FAU - Gubin, D G
AU  - Gubin DG
AUID- ORCID: 0000-0003-2028-1033
AD  - a Department of Biology , Medical University , Tyumen , Russia.
FAU - Nelaeva, A A
AU  - Nelaeva AA
AD  - b Department of Endocrinology , Medical University , Tyumen , Russia.
FAU - Uzhakova, A E
AU  - Uzhakova AE
AD  - b Department of Endocrinology , Medical University , Tyumen , Russia.
FAU - Hasanova, Y V
AU  - Hasanova YV
AD  - b Department of Endocrinology , Medical University , Tyumen , Russia.
FAU - Cornelissen, G
AU  - Cornelissen G
AD  - c Halberg Chronobiology Center , University of Minnesota , Minneapolis , MN , 
      USA.
FAU - Weinert, D
AU  - Weinert D
AD  - d Institute of Biology/Zoology , Martin Luther University , Halle-Wittenberg , 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20170731
PL  - England
TA  - Chronobiol Int
JT  - Chronobiology international
JID - 8501362
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Body Temperature/*physiology
MH  - Circadian Rhythm/physiology
MH  - Diabetes Mellitus, Type 2/*metabolism/physiopathology
MH  - Fasting/*physiology
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/metabolism
OTO - NOTNLM
OT  - 24-h (circadian) rhythms
OT  - Body temperature
OT  - body mass index
OT  - circadian disruption
OT  - fasting blood glucose
OT  - heart rate
OT  - metabolic state
OT  - prediabetes
OT  - type 2 diabetes mellitus
EDAT- 2017/08/02 06:00
MHDA- 2018/07/25 06:00
CRDT- 2017/08/01 06:00
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/07/25 06:00 [medline]
PHST- 2017/08/01 06:00 [entrez]
AID - 10.1080/07420528.2017.1347670 [doi]
PST - ppublish
SO  - Chronobiol Int. 2017;34(8):1136-1148. doi: 10.1080/07420528.2017.1347670. Epub 
      2017 Jul 31.