PMID- 28759707
OWN - NLM
STAT- MEDLINE
DCOM- 20180126
LR  - 20180126
IS  - 1099-0461 (Electronic)
IS  - 1095-6670 (Linking)
VI  - 31
IP  - 11
DP  - 2017 Nov
TI  - Relevance of cystatin-C, N-acetylglucosaminidase, and Interleukin-18 with the 
      diagnosis of acute kidney injury induced by cadmium in rats.
LID - 10.1002/jbt.21968 [doi]
AB  - The diagnosis of acute kidney injury (AKI) is frequently established on 
      modifications in serum creatinine (SCr). The discriminative and prognostic 
      aptitudes of serum cystatin-C as well as N-acetylglucosaminidase (NAG) and 
      Interleukin-18 (IL-18) were inspected for the estimation of AKI. In this study 
      twelve rats were alienated into two groups: control group received saline, second 
      group received cadmium chloride at a dose (2.4 mg Cd/kg/day, i.p) for 30 days. 
      Blood urea nitrogen (BUN), SCr, and IL-18 serum level were measured in addition 
      to serum and tissue content of cystatin-C and NAG. AKI model showed significant 
      increase in BUN, creatinine, and IL-18. RT-PCR showed upregulation of cystatin-C 
      gene besides significant increase of its level in serum. Additionally, tissue 
      content of NAG was significantly increased. Our findings may provide that 
      grouping of several biomarkers for diagnosis of AKI is a more valuable diagnostic 
      tool than single-marker measurement.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Mohamed Ali, Ola Sayed
AU  - Mohamed Ali OS
AD  - Department of Biochemistry, Faculty of Pharmacy (Girls), Al Azhar University, 
      Cairo, Egypt.
FAU - Elshaer, Shereen Saeid
AU  - Elshaer SS
AUID- ORCID: 0000-0001-9835-8913
AD  - Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, 
      Cairo, Egypt.
FAU - Anwar, Hend Mohamed
AU  - Anwar HM
AUID- ORCID: 0000-0001-7940-7126
AD  - Department of Biochemistry, National Organization for Drug Control and Research, 
      Giza, Egypt.
FAU - Zohni, Mamdouh Salah El-Din
AU  - Zohni MSE
AD  - Department of Biochemistry, National Organization for Drug Control & Research, 
      Giza, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20170731
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 0 (Biomarkers)
RN  - 0 (Cystatin C)
RN  - 0 (Interleukin-18)
RN  - 00BH33GNGH (Cadmium)
RN  - EC 3.2.1.52 (Acetylglucosaminidase)
SB  - IM
MH  - Acetylglucosaminidase/metabolism
MH  - Acute Kidney Injury/*chemically induced/*diagnosis/metabolism
MH  - Animals
MH  - Biomarkers/blood
MH  - Blood Urea Nitrogen
MH  - Cadmium/*toxicity
MH  - Cystatin C/*blood/genetics
MH  - Gene Expression Regulation/drug effects
MH  - Interleukin-18/*blood
MH  - Male
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Interleukin-18
OT  - N-acetylglucosaminidase
OT  - acute kidney injury
OT  - cystatin-c
OT  - real-time polymerase chain reaction
EDAT- 2017/08/02 06:00
MHDA- 2018/01/27 06:00
CRDT- 2017/08/01 06:00
PHST- 2017/05/22 00:00 [received]
PHST- 2017/07/03 00:00 [revised]
PHST- 2017/07/11 00:00 [accepted]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/01/27 06:00 [medline]
PHST- 2017/08/01 06:00 [entrez]
AID - 10.1002/jbt.21968 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2017 Nov;31(11). doi: 10.1002/jbt.21968. Epub 2017 Jul 31.