PMID- 28760936
OWN - NLM
STAT- MEDLINE
DCOM- 20171017
LR  - 20201209
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Print)
IS  - 0019-9567 (Linking)
VI  - 85
IP  - 10
DP  - 2017 Oct
TI  - Caspase-11 Plays a Protective Role in Pulmonary Acinetobacter baumannii 
      Infection.
LID - 10.1128/IAI.00350-17 [doi]
LID - e00350-17
AB  - Activation of caspase-11 by some Gram-negative bacteria triggers the 
      caspase-1/interleukin 1beta (IL-1beta) pathway, independent of canonical inflammasomes. 
      Acinetobacter baumannii is a Gram-negative, conditionally pathogenic bacterium 
      that can cause severe pulmonary infection in hospitalized patients. A. baumannii 
      was revealed to activate canonical and noncanonical inflammasome pathways in bone 
      marrow-derived macrophages (BMDMs). Pulmonary infection of caspase-11(-/-) mice 
      with A. baumannii showed that caspase-11 deficiency impaired A. baumannii 
      clearance, exacerbated pulmonary pathological changes, and enhanced 
      susceptibility to A. baumannii These data indicate that the caspase-11-mediated 
      innate immune response plays a crucial role in defending against A. baumannii.
CI  - Copyright (c) 2017 American Society for Microbiology.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Pathophysiology, College of Basic Medical Science, China Medical 
      University, Shenyang, China.
FAU - Shao, Yue
AU  - Shao Y
AD  - Department of Pathophysiology, College of Basic Medical Science, China Medical 
      University, Shenyang, China.
FAU - Li, Shengjun
AU  - Li S
AD  - Department of Immunology, College of Basic Medical Science, China Medical 
      University, Shenyang, China.
FAU - Xin, Na
AU  - Xin N
AD  - Department of Pathophysiology, College of Basic Medical Science, China Medical 
      University, Shenyang, China.
FAU - Ma, Tingxian
AU  - Ma T
AD  - Department of Pathophysiology, College of Basic Medical Science, China Medical 
      University, Shenyang, China.
FAU - Zhao, Chenghai
AU  - Zhao C
AUID- ORCID: 0000-0003-2246-1425
AD  - Department of Pathophysiology, College of Basic Medical Science, China Medical 
      University, Shenyang, China zhaochenghai1@sina.com minsongli@sina.com.
FAU - Song, Min
AU  - Song M
AD  - Department of Pathology, College of Basic Medical Science, China Medical 
      University, Shenyang, China zhaochenghai1@sina.com minsongli@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20170920
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - EC 3.4.22.- (Casp4 protein, mouse)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (Caspases, Initiator)
SB  - IM
MH  - Acinetobacter Infections/enzymology/*immunology/prevention & control
MH  - Acinetobacter baumannii/*immunology/metabolism/pathogenicity
MH  - Animals
MH  - Caspases/deficiency/genetics/*metabolism
MH  - Caspases, Initiator
MH  - *Immunity, Innate
MH  - Inflammasomes/immunology
MH  - Interleukin-1beta/immunology
MH  - Lung/immunology/microbiology/pathology
MH  - Macrophages/*immunology/microbiology
MH  - Mice
MH  - Mice, Knockout
MH  - Respiratory Tract Infections/enzymology/*immunology/pathology
PMC - PMC5607408
OTO - NOTNLM
OT  - A. baumannii
OT  - caspase-1
OT  - caspase-11
OT  - inflammasome
EDAT- 2017/08/02 06:00
MHDA- 2017/10/19 06:00
PMCR- 2018/03/20
CRDT- 2017/08/02 06:00
PHST- 2017/05/17 00:00 [received]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2017/10/19 06:00 [medline]
PHST- 2017/08/02 06:00 [entrez]
PHST- 2018/03/20 00:00 [pmc-release]
AID - IAI.00350-17 [pii]
AID - 00350-17 [pii]
AID - 10.1128/IAI.00350-17 [doi]
PST - epublish
SO  - Infect Immun. 2017 Sep 20;85(10):e00350-17. doi: 10.1128/IAI.00350-17. Print 2017 
      Oct.