PMID- 28761074
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20220410
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jul 31
TI  - Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in 
      chronic unpredictable mild stress mice and its related mechanism.
PG  - 6903
LID - 10.1038/s41598-017-07407-1 [doi]
LID - 6903
AB  - The aim of this study was to evaluate whether Schisandra chinensis extract (SCE) 
      administration influences chronic unpredictable mild stress (CUMS)-induced 
      depression and cognitive impairment, and explores underlying mechanisms. Sucrose 
      preference test (SPT) and forced swimming test (FST) were used for assessing 
      depressive symptoms, and Y-maze, Morris water maze were used for evaluating 
      cognition processes. The results showed that CUMS (4 weeks) was effective in 
      producing both depression and memory deficits in mice. Additionally, CUMS 
      exposure significantly decreased brain derived neurotrophic factor (BDNF) levels 
      in hippocampus as indicated by ELISA, immunohistochemistry and immunofluorescence 
      assays, accompanied by down-regulated tyrosine kinase receptor B 
      (TrkB)/cAMP-response element binding protein (CREB)/extracellular 
      signal-regulated kinase (ERK) and phosphatidylinositol 3 kinase (PI3K)/ protein 
      kinase B (AKT)/ glycogen synthase kinase-3beta (GSK-3beta) signaling pathways. Chronic 
      administration of SCE (600 or 1200 mg/kg, i.g.) significantly prevented all these 
      CUMS-induced behavioral and biochemical alterations. It suggested that SCE could 
      improve the depression-like emotional status and associated cognitive deficits in 
      CUMS mice, which might be mediated by regulation of BDNF levels in hippocampus, 
      as well as up-regulating of TrkB/CREB/ERK and PI3K/AKT/GSK-3beta pathways.
FAU - Yan, Tingxu
AU  - Yan T
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, 110016, China.
FAU - He, Bosai
AU  - He B
AD  - School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, 
      Shenyang, 110016, China.
FAU - Wan, Shutong
AU  - Wan S
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, 110016, China.
FAU - Xu, Mengjie
AU  - Xu M
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, 110016, China.
FAU - Yang, Huilin
AU  - Yang H
AD  - School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 
      Wenhua Road 103, Shenyang, 110016, China.
FAU - Xiao, Feng
AU  - Xiao F
AD  - School of Functional Food and Wine, Shenyang Pharmaceutical University, Wenhua 
      Road 103, Shenyang, 110016, China.
FAU - Bi, Kaishun
AU  - Bi K
AD  - School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, 
      Shenyang, 110016, China.
FAU - Jia, Ying
AU  - Jia Y
AD  - School of Functional Food and Wine, Shenyang Pharmaceutical University, Wenhua 
      Road 103, Shenyang, 110016, China. jiayingsyphu@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170731
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Nootropic Agents)
RN  - 0 (Plant Extracts)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.3.1.48 (Crebbp protein, mouse)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - CREB-Binding Protein/metabolism
MH  - Depression/*drug therapy/etiology/metabolism
MH  - Disease Models, Animal
MH  - Gene Expression Regulation
MH  - Hippocampus/metabolism
MH  - Male
MH  - Maze Learning
MH  - Membrane Glycoproteins/metabolism
MH  - Memory Disorders/*drug therapy/etiology/metabolism
MH  - Mice
MH  - Nootropic Agents/*administration & dosage/pharmacology
MH  - Plant Extracts/*administration & dosage/pharmacology
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Schisandra/*chemistry
MH  - Signal Transduction/drug effects
MH  - Stress, Psychological/complications/*drug therapy/metabolism
MH  - Swimming
PMC - PMC5537344
COIS- The authors declare that they have no competing interests.
EDAT- 2017/08/02 06:00
MHDA- 2019/03/21 06:00
PMCR- 2017/07/31
CRDT- 2017/08/02 06:00
PHST- 2017/02/15 00:00 [received]
PHST- 2017/06/28 00:00 [accepted]
PHST- 2017/08/02 06:00 [entrez]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2017/07/31 00:00 [pmc-release]
AID - 10.1038/s41598-017-07407-1 [pii]
AID - 7407 [pii]
AID - 10.1038/s41598-017-07407-1 [doi]
PST - epublish
SO  - Sci Rep. 2017 Jul 31;7(1):6903. doi: 10.1038/s41598-017-07407-1.