PMID- 28761286
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1013-9087 (Print)
IS  - 2005-3894 (Electronic)
IS  - 1013-9087 (Linking)
VI  - 29
IP  - 4
DP  - 2017 Aug
TI  - House Dust Mite Sensitization Is Inversely Associated with Plasma 
      25-Hydroxyvitamin D3 Levels in Patients with Severe Atopic Dermatitis.
PG  - 400-406
LID - 10.5021/ad.2017.29.4.400 [doi]
AB  - BACKGROUND: The relationship between atopic dermatitis (AD) and low vitamin D 
      levels has been studied. Emerging evidence has implicated vitamin D as a critical 
      regulator of immunity, playing a role in both the innate and cell-mediated immune 
      systems. However, the effect of vitamin D on house dust mite (HDM) sensitization 
      in patients with AD has not been established. OBJECTIVE: We investigated the 
      association between vitamin D levels and HDM sensitization according to AD 
      severity. METHODS: In total, 80 patients (43 men and 37 women) with AD were 
      included. We classified AD severity using Rajka and Langeland scores. Laboratory 
      tests included serum 25-hydroxyvitamin D3, total immunoglobulin E (IgE), and 
      specific IgE antibody titer against Dermatophagoides farinae and D. 
      pteronyssinus. RESULTS: There were no differences in vitamin D levels between the 
      mild or moderate AD and severe AD groups. In the severe AD group, high HDM 
      sensitization group had lower serum vitamin D levels compared to low HDM 
      sensitization group with statistical significance. In addition, a significant 
      negative correlation was found between vitamin D levels and HDM sensitization in 
      the severe AD group. CONCLUSION: Our results demonstrate that low vitamin D 
      levels may link to high HDM sensitization in patients with the severe AD. Further 
      elucidation of the role of vitamin D in HDM sensitization may hold profound 
      implications for the prevention and treatment of AD.
FAU - Jang, Yong Hyun
AU  - Jang YH
AD  - Department of Dermatology, Kyungpook National University School of Medicine, 
      Daegu, Korea.
FAU - Sim, Hyun Bo
AU  - Sim HB
AD  - Department of Dermatology, Kyungpook National University School of Medicine, 
      Daegu, Korea.
FAU - Moon, Sun Young
AU  - Moon SY
AD  - Department of Dermatology, Kyungpook National University School of Medicine, 
      Daegu, Korea.
FAU - Lee, Weon Ju
AU  - Lee WJ
AD  - Department of Dermatology, Kyungpook National University School of Medicine, 
      Daegu, Korea.
FAU - Lee, Seok-Jong
AU  - Lee SJ
AD  - Department of Dermatology, Kyungpook National University School of Medicine, 
      Daegu, Korea.
FAU - Jin, Meiling
AU  - Jin M
AD  - Department of Pharmacology, Kyungpook National University School of Medicine, 
      Daegu, Korea.
FAU - Kim, Sang-Hyun
AU  - Kim SH
AD  - Department of Pharmacology, Kyungpook National University School of Medicine, 
      Daegu, Korea.
FAU - Kim, Do Won
AU  - Kim DW
AD  - Department of Dermatology, Kyungpook National University School of Medicine, 
      Daegu, Korea.
LA  - eng
PT  - Journal Article
DEP - 20170621
PL  - Korea (South)
TA  - Ann Dermatol
JT  - Annals of dermatology
JID - 8916577
PMC - PMC5500703
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Dermatophagoides farinae
OT  - Dermatophagoides pteronyssinus
OT  - Sensitization
OT  - Vitamin D
COIS- CONFLICTS OF INTEREST: The authors have nothing to disclose.
EDAT- 2017/08/02 06:00
MHDA- 2017/08/02 06:01
PMCR- 2017/08/01
CRDT- 2017/08/02 06:00
PHST- 2016/07/18 00:00 [received]
PHST- 2016/08/31 00:00 [accepted]
PHST- 2017/08/02 06:00 [entrez]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2017/08/02 06:01 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - 10.5021/ad.2017.29.4.400 [doi]
PST - ppublish
SO  - Ann Dermatol. 2017 Aug;29(4):400-406. doi: 10.5021/ad.2017.29.4.400. Epub 2017 
      Jun 21.