PMID- 28761578
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0011-393X (Print)
IS  - 1879-0313 (Electronic)
IS  - 0011-393X (Linking)
VI  - 84
DP  - 2017
TI  - Esophageal Motility and Rikkunshito Treatment for Proton Pump 
      Inhibitor-Refractory Nonerosive Reflux Disease: A Prospective, Uncontrolled, 
      Open-Label Pilot Study Trial.
PG  - 37-41
LID - 10.1016/j.curtheres.2017.03.007 [doi]
AB  - BACKGROUND: Only a few reports focused on esophageal motility in patients with 
      proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) and there 
      has been no established strategy for treatment. OBJECTIVE: To clarify the 
      characteristics of esophageal motility in patients with PPI-refractory NERD, we 
      evaluated esophageal function using combined multichannel intraluminal impedance 
      and esophageal manometry (MII-EM). In addition, we evaluated the efficacy of 
      rikkunshito (RKT), which is a gastrointestinal prokinetic agent. METHODS: Thirty 
      patients with NERD were enrolled and underwent MII-EM. After 8 weeks of RKT (7.5 
      g/d) treatment, MII-EM was repeated on patients with PPI-refractory NERD. 
      Symptoms were assessed by the Gastrointestinal Symptom Rating Scale. RESULTS: In 
      patients with PPI-refractory NERD, measures of complete bolus transit, 
      peristaltic contractions, and residual pressure of the lower esophageal sphincter 
      during swallowing deviated from the standard values and esophageal clearance was 
      found to be deteriorated. RKT significantly improved the peristaltic contractions 
      (P < 0.05), the complete bolus transit (P < 0.01), and the residual pressure of 
      lower esophageal sphincter (P < 0.05) in these patients. The overall score (P < 
      0.01) and the subscale scores of acid reflux syndrome (P < 0.05), abdominal pain 
      (P < 0.05), and indigestion syndrome (P < 0.01) in the Gastrointestinal Symptom 
      Rating Scale were significantly improved by the 8-week RKT treatment. 
      CONCLUSIONS: In the pilot study, patients with PPI-refractory NERD had disorders 
      of esophageal and lower esophageal sphincter motility that were improved by RKT. 
      Further studies examining esophageal motor activity of RKT in PPI-refractory NERD 
      are required. University hospital Medical Information Network (UMIN) Clinical 
      Trial Registry identifier: UMIN000003092.
FAU - Odaka, Takeo
AU  - Odaka T
AD  - Odaka Medical and Gastrointestinal Clinic, Chiba, Japan.
FAU - Yamato, Shigeru
AU  - Yamato S
AD  - Division of Gastroenterology, National Center of Neurology & Psychiatry, Tokyo, 
      Japan.
FAU - Yokosuka, Osamu
AU  - Yokosuka O
AD  - Funabashi Central Hospital, Chiba, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170404
PL  - United States
TA  - Curr Ther Res Clin Exp
JT  - Current therapeutic research, clinical and experimental
JID - 0372621
PMC - PMC5522981
OTO - NOTNLM
OT  - esophageal motility
OT  - high-resolution impedance manometry
OT  - non-erosive reflux disease
OT  - proton pump inhibitor
OT  - rikkunshito
EDAT- 2017/08/02 06:00
MHDA- 2017/08/02 06:01
PMCR- 2017/04/04
CRDT- 2017/08/02 06:00
PHST- 2017/03/28 00:00 [accepted]
PHST- 2017/08/02 06:00 [entrez]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2017/08/02 06:01 [medline]
PHST- 2017/04/04 00:00 [pmc-release]
AID - S0011-393X(17)30019-X [pii]
AID - 10.1016/j.curtheres.2017.03.007 [doi]
PST - epublish
SO  - Curr Ther Res Clin Exp. 2017 Apr 4;84:37-41. doi: 
      10.1016/j.curtheres.2017.03.007. eCollection 2017.