PMID- 28761879
OWN - NLM
STAT- MEDLINE
DCOM- 20180501
LR  - 20221207
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2017
DP  - 2017
TI  - Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in 
      Chinese Patients with T2DM.
PG  - 8756978
LID - 10.1155/2017/8756978 [doi]
LID - 8756978
AB  - OBJECTIVE: To investigate the relationship between alcohol consumption and 
      diabetic lower extremity arterial disease (LEAD) in hospitalized patients with 
      type 2 diabetes mellitus (T2DM). METHODS: We evaluated 138 hospitalized patients 
      with T2DM who consumed alcohol and 833 who did not. We used propensity score 
      matching to reduce the confounding bias between groups. Additionally, a logistic 
      regression analysis was performed with the matched data to evaluate the LEAD 
      risk. RESULTS: In total, 119 pairs of patients who did and did not consume 
      alcohol were matched. According to the logistic regression analysis, patients who 
      consumed >8 U of alcohol/day had a higher risk of LEAD (odds ratio (OR): 6.35, 
      95% confidence interval (CI): 1.78-22.65) than patients who did not consume 
      alcohol. Additionally, after adjusting for age, gender, region, occupation, 
      smoking status, body mass index, weight change, and duration of diabetes, the OR 
      of peripheral artery disease after >20 years of alcohol consumption was 3.48 (95% 
      CI: 1.09-11.15). Furthermore, we observed a significant dose-response 
      relationship between alcohol consumption and LEAD. CONCLUSIONS: Alcohol 
      consumption may be a risk factor of LEAD in patients with T2DM. Patients with 
      T2DM should be advised to stop drinking, to prevent the onset of LEAD.
FAU - Yang, Shanshan
AU  - Yang S
AD  - Institute of Geriatrics, Beijing Key Laboratory of Ageing and Geriatrics, State 
      Key Laboratory of Kidney Disease, Chinese PLA General Hospital, 28 Fuxing Road, 
      Beijing 100853, China.
AD  - Jinan Military Area CDC, Jinan, Shandong 250014, China.
FAU - Wang, Shuang
AU  - Wang S
AUID- ORCID: 0000-0002-1753-0062
AD  - Department of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, 
      China.
FAU - Yang, Bo
AU  - Yang B
AUID- ORCID: 0000-0002-5612-1122
AD  - Department of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, 
      China.
FAU - Zheng, Jinliang
AU  - Zheng J
AUID- ORCID: 0000-0002-5748-4099
AD  - Department of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, 
      China.
FAU - Cai, Yuping
AU  - Cai Y
AUID- ORCID: 0000-0003-4841-5726
AD  - Department of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, 
      China.
FAU - Yang, Zhengguo
AU  - Yang Z
AUID- ORCID: 0000-0001-7972-835X
AD  - Department of Nephrology and Endocrinology, PLA 148th Hospital, Zibo 255300, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20170706
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alcohol Drinking/*adverse effects/ethnology
MH  - Asian People
MH  - Chi-Square Distribution
MH  - China
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/ethnology
MH  - Diabetic Angiopathies/diagnosis/ethnology/*etiology
MH  - Female
MH  - Humans
MH  - Inpatients
MH  - Logistic Models
MH  - Lower Extremity/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Peripheral Arterial Disease/diagnosis/ethnology/*etiology
MH  - Propensity Score
MH  - Risk Assessment
MH  - Risk Factors
MH  - Young Adult
PMC - PMC5518525
EDAT- 2017/08/02 06:00
MHDA- 2018/05/02 06:00
PMCR- 2017/07/06
CRDT- 2017/08/02 06:00
PHST- 2017/03/07 00:00 [received]
PHST- 2017/05/22 00:00 [revised]
PHST- 2017/05/28 00:00 [accepted]
PHST- 2017/08/02 06:00 [entrez]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/05/02 06:00 [medline]
PHST- 2017/07/06 00:00 [pmc-release]
AID - 10.1155/2017/8756978 [doi]
PST - ppublish
SO  - J Diabetes Res. 2017;2017:8756978. doi: 10.1155/2017/8756978. Epub 2017 Jul 6.