PMID- 28763025
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20231213
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 22
IP  - 8
DP  - 2017 Aug 1
TI  - Effect of Sunlight Radiation on the Growth and Chemical Constituents of Salvia 
      plebeia R.Br.
LID - 10.3390/molecules22081279 [doi]
LID - 1279
AB  - This study investigated the chemical composition changes of Salvia plebeia R.Br. 
      cultivated under different light sources, including florescent light and 
      sunlight. The plants were exposed to fluorescent light for four months and 
      sunlight and then examined for the next 5-7 months. Plants were harvested monthly 
      during the seven months, and we examined whether the difference in light source 
      affected the phenolic and flavonoid contents and antioxidant activity. A simple 
      and reliable HPLC method using a PAH C(18) column was applied for the 
      quantitative analysis of two triterpenoids from the S. plebeia groups. Oleanolic 
      acid (OA) and ursolic acid (UA) showed good linearity (R(2) > 0.9999) within the 
      test ranges (0.005-0.05 mg/mL), and the average percentage recoveries of the OA 
      and UA were 95.1-104.8% and 97.2-107.1%, respectively. The intra- and inter-day 
      relative standard deviations (RSDs) were less than 2.0%. After exposure to 
      sunlight, the phenolic contents, including rosmarinic acid, showed a reduced 
      tendency, whereas the flavonoid contents, including homoplantaginin and luteolin 
      7-glucoside, were increased. The content of the triterpenoids also showed an 
      increased tendency under sunlight irradiation, but the variance was not larger 
      than those of the phenolic and flavonoid contents. Among experimental groups, the 
      group harvested at six months, having been exposed to sunlight for two months, 
      showed the most potent antioxidant activity. Therefore, these results showed that 
      the chemical composition and antioxidant activities of S. plebeia R.Br. was 
      affected from environmental culture conditions, such as light source. Our studies 
      will be useful for the development of functional materials using S. plebeia R.Br.
FAU - Jang, Hyun-Jae
AU  - Jang HJ
AD  - Immunoregulatory Material Research Center, Korea Research Institute of Bioscience 
      and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea. 
      water815@kribb.re.kr.
FAU - Lee, Seung-Jae
AU  - Lee SJ
AD  - Immunoregulatory Material Research Center, Korea Research Institute of Bioscience 
      and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea. 
      seung99@kribb.re.kr.
FAU - Kim, Cha Young
AU  - Kim CY
AD  - Biological Resource Center, Korea Research Institute of Bioscience and 
      Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea. 
      kimcy@kribb.re.kr.
FAU - Hwang, Joo Tae
AU  - Hwang JT
AD  - Immunoregulatory Material Research Center, Korea Research Institute of Bioscience 
      and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea. 
      jthwang@kiom.re.kr.
FAU - Choi, Jung Ho
AU  - Choi JH
AD  - R&D Center, Korean Drug Co., Ltd., Seoul 06300, Korea. bearlss@hanmail.net.
FAU - Park, Jee Hun
AU  - Park JH
AD  - R&D Center, Korean Drug Co., Ltd., Seoul 06300, Korea. wlgns1010@hanmail.net.
FAU - Lee, Seung Woong
AU  - Lee SW
AD  - Immunoregulatory Material Research Center, Korea Research Institute of Bioscience 
      and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea. 
      lswdoc@kribb.re.kr.
FAU - Rho, Mun-Chual
AU  - Rho MC
AD  - Immunoregulatory Material Research Center, Korea Research Institute of Bioscience 
      and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea. 
      rho-m@kribb.re.kr.
LA  - eng
PT  - Journal Article
DEP - 20170801
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 0 (Phenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Triterpenes)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
SB  - IM
MH  - Animals
MH  - Antioxidants/chemistry/pharmacology
MH  - Chromatography, High Pressure Liquid
MH  - Flavonoids/chemistry
MH  - Humans
MH  - Mice
MH  - Molecular Structure
MH  - Oleanolic Acid/chemistry/pharmacology
MH  - Phenols/chemistry
MH  - Photosynthesis
MH  - Plant Extracts/*chemistry
MH  - RAW 264.7 Cells
MH  - Salvia/chemistry/growth & development/*radiation effects
MH  - *Sunlight
MH  - Triterpenes/chemistry/pharmacology
MH  - Ursolic Acid
PMC - PMC6152347
OTO - NOTNLM
OT  - HPLC validation
OT  - Salvia plebeia
OT  - UV
OT  - antioxidant
OT  - cultivation
OT  - flavonoid
OT  - triterpenoid
COIS- The authors declare no conflicts of interest.
EDAT- 2017/08/02 06:00
MHDA- 2018/04/03 06:00
PMCR- 2017/08/01
CRDT- 2017/08/02 06:00
PHST- 2017/07/10 00:00 [received]
PHST- 2017/07/26 00:00 [revised]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2017/08/02 06:00 [entrez]
PHST- 2017/08/02 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - molecules22081279 [pii]
AID - molecules-22-01279 [pii]
AID - 10.3390/molecules22081279 [doi]
PST - epublish
SO  - Molecules. 2017 Aug 1;22(8):1279. doi: 10.3390/molecules22081279.