PMID- 28764913
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20220316
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 79
IP  - Pt B
DP  - 2017 Oct 3
TI  - microRNA-124 targets glucocorticoid receptor and is involved in depression-like 
      behaviors.
PG  - 417-425
LID - S0278-5846(17)30338-X [pii]
LID - 10.1016/j.pnpbp.2017.07.024 [doi]
AB  - Dysregulation of microRNA (miRNA) has been shown to be involved in early 
      observations of depression. MicroRNA-124-3p (miR-124) is the most abundant 
      microRNA in the brain. Previous studies have shown that miR-124 plays a major 
      role in depression. Here we showed that miR-124 directly targeted glucocorticoid 
      receptor (GR) in HEK 293 cells. In addition, inhibition of miR-124 by its 
      antagomir (2nmol/every two days) could reverse the decrease of sucrose preference 
      and the increase of immobility time in mice exposed to chronic corticosterone 
      (CORT, 40mg/kg) injection. Moreover, these effects on behavioral improvement were 
      coupled to the activation of brain-derived neurotrophic factor (BDNF), TrkB, ERK, 
      and CREB, as well as the induction of synaptogenesis and neuronal proliferation. 
      Altogether, our study suggests that miR-124 can be served as a biomarker for 
      depression and a novel target for drug development, and demonstrates that 
      inhibition of miR-124 may be a strategy for treating depression by activating 
      BDNF-TrkB signaling pathway in the hippocampus.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Wang, Shuang-Shuang
AU  - Wang SS
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China; 
      Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, 
      Fujian Province, PR China.
FAU - Mu, Rong-Hao
AU  - Mu RH
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China; 
      Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, 
      Fujian Province, PR China.
FAU - Li, Cheng-Fu
AU  - Li CF
AD  - Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361009, Fujian Province, 
      PR China.
FAU - Dong, Shu-Qi
AU  - Dong SQ
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China; 
      Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, 
      Fujian Province, PR China.
FAU - Geng, Di
AU  - Geng D
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China; Fujian 
      Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 
      361021, Fujian Province, PR China; Institute of Pharmaceutical Engineering, 
      Huaqiao University, Xiamen 361021, Fujian Province, PR China.
FAU - Liu, Qing
AU  - Liu Q
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China; Fujian 
      Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 
      361021, Fujian Province, PR China; Institute of Pharmaceutical Engineering, 
      Huaqiao University, Xiamen 361021, Fujian Province, PR China.
FAU - Yi, Li-Tao
AU  - Yi LT
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian Province, PR China; Fujian 
      Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 
      361021, Fujian Province, PR China; Institute of Pharmaceutical Engineering, 
      Huaqiao University, Xiamen 361021, Fujian Province, PR China. Electronic address: 
      litaoyi@hqu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170729
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Antagomirs)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MIRN124 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn124 microRNA, mouse)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Glucocorticoid)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antagomirs/pharmacology
MH  - Antidepressive Agents/pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone
MH  - Depressive Disorder/drug therapy/*metabolism/pathology
MH  - Disease Models, Animal
MH  - HEK293 Cells
MH  - Hippocampus/drug effects/metabolism/pathology
MH  - Humans
MH  - Male
MH  - Mice, Inbred C57BL
MH  - MicroRNAs/antagonists & inhibitors/*metabolism
MH  - Neurons/drug effects/metabolism/pathology
MH  - Protein Interaction Domains and Motifs
MH  - RNA, Messenger/metabolism
MH  - Random Allocation
MH  - Receptors, Glucocorticoid/genetics/*metabolism
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Depression
OT  - Glucocorticoid receptor (GR)
OT  - Hippocampus
OT  - microRNA (miRNA)
EDAT- 2017/08/03 06:00
MHDA- 2018/06/13 06:00
CRDT- 2017/08/03 06:00
PHST- 2017/05/01 00:00 [received]
PHST- 2017/07/15 00:00 [revised]
PHST- 2017/07/28 00:00 [accepted]
PHST- 2017/08/03 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
PHST- 2017/08/03 06:00 [entrez]
AID - S0278-5846(17)30338-X [pii]
AID - 10.1016/j.pnpbp.2017.07.024 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):417-425. doi: 
      10.1016/j.pnpbp.2017.07.024. Epub 2017 Jul 29.