PMID- 28765058
OWN - NLM
STAT- MEDLINE
DCOM- 20180511
LR  - 20181202
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 45
DP  - 2017 Nov
TI  - Changes in cerebral metabolites in type 2 diabetes mellitus: A meta-analysis of 
      proton magnetic resonance spectroscopy.
PG  - 9-13
LID - S0967-5868(16)31292-9 [pii]
LID - 10.1016/j.jocn.2017.07.017 [doi]
AB  - To investigate whether there were differences and consistent patterns that 
      highlight and consolidate the metabolite changes in type 2 diabetes mellitus 
      (T2DM), a meta-analysis of proton magnetic resonance spectroscopy (MRS) was 
      conducted. PubMed, Web of Science, and Embase databases were searched up to 
      August 2016 for collecting the relevant studies. After an inclusion and exclusion 
      criteria, the data was extracted. The data was analyzed using Stata software 
      v.12.0. The weight mean difference (MD) and 95% confidence interval (CI) were 
      used to compare continuous variables. A total of 10 studies (with a total of 244 
      T2DM patients and 223 healthy controls) were included. N-Acetyl Aspartate 
      (NAA)/creatine (Cr) levels were decreased in the frontal lobe (MD=-0.20, 
      95%CI=-0.33 to -0.06, P=0.005) and lenticular nucleus (MD=-0.14, 95%CI=-0.22 to 
      -0.06, P=0.001); choline (Cho)/Cr levels were increased in the lenticular nucleus 
      (MD=0.15, 95%CI=0.02-0.28, P=0.025); myo-inositol (MI)/Cr levels were increased 
      in the in the occipital lobe (MD=0.11, 95%CI=0.02-0.19, P=0.017) and parietal 
      lobe (MD=0.16, 95%CI=0.05-0.28, P=0.006); MI levels were increased in the frontal 
      white matter (MD=0.52, 95%CI=0.14-0.90, P=0.008). The results of our 
      meta-analysis indicated that metabolite levels were altered in different regions 
      of brain, which may be shown with MRS and caused clinical symptoms in T2DM 
      further.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Wu, Guang-Yao
AU  - Wu GY
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, 
      Dalian 116001, China; Department of Mathematical Information Technology, 
      University of Jyvaskyla, Jyvaskyla, Finland.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, 
      Dalian 116001, China.
FAU - Wu, Jian-Lin
AU  - Wu JL
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, 
      Dalian 116001, China. Electronic address: cjr.wujianlin@vip.163.com.
FAU - Jing, Li
AU  - Jing L
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, 
      Dalian 116001, China.
FAU - Tan, Yang
AU  - Tan Y
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, 
      Dalian 116001, China.
FAU - Qiu, Tai-Chun
AU  - Qiu TC
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, 
      Dalian 116001, China.
FAU - Zhao, Jiao
AU  - Zhao J
AD  - Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, 
      Dalian 116001, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20170729
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 4L6452S749 (Inositol)
RN  - 997-55-7 (N-acetylaspartate)
RN  - MU72812GK0 (Creatine)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Aspartic Acid/analogs & derivatives/metabolism
MH  - Brain/diagnostic imaging/*metabolism
MH  - Case-Control Studies
MH  - Choline/metabolism
MH  - Creatine/metabolism
MH  - Diabetes Mellitus, Type 2/diagnostic imaging/*metabolism
MH  - Humans
MH  - Inositol/metabolism
MH  - Proton Magnetic Resonance Spectroscopy/adverse effects/*methods
OTO - NOTNLM
OT  - Magnetic resonance spectroscopy
OT  - Meta-analysis
OT  - Type 2 diabetes mellitus
EDAT- 2017/08/03 06:00
MHDA- 2018/05/12 06:00
CRDT- 2017/08/03 06:00
PHST- 2016/11/21 00:00 [received]
PHST- 2017/06/19 00:00 [revised]
PHST- 2017/07/11 00:00 [accepted]
PHST- 2017/08/03 06:00 [pubmed]
PHST- 2018/05/12 06:00 [medline]
PHST- 2017/08/03 06:00 [entrez]
AID - S0967-5868(16)31292-9 [pii]
AID - 10.1016/j.jocn.2017.07.017 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2017 Nov;45:9-13. doi: 10.1016/j.jocn.2017.07.017. Epub 2017 Jul 
      29.