PMID- 28765949
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20180514
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 16
IP  - 4
DP  - 2017 Oct
TI  - Identification of miRNA-mRNA crosstalk in laryngeal squamous cell carcinoma.
PG  - 4179-4186
LID - 10.3892/mmr.2017.7123 [doi]
AB  - The aim of the present study was to elaborate the underlying pathogenesis of 
      laryngeal squamous cell carcinoma (LSCC). Micro (mi) RNA and messenger (m) RNA 
      expression profiling of patients with LSCC were downloaded from The Cancer Genome 
      Atlas (TCGA) database. Differentially expressed miRNAs (DEMIs) and differentially 
      expressed mRNAs (DEMs) were identified in LSCC compared to normal control 
      tissues. The DEMs targeted by DEMIs were identified and the negative correlation 
      between DEMs and DEMIs was subjected to visualization. The potential functions of 
      DEMs targeted by DEMIs were annotated in Gene Ontology (GO) and Kyoto 
      Encyclopedia of Genes and Genomes (KEGG) database. A total of 663 dysregulated 
      DEMs (449 upregulated and 214 downregulated) and 33 DEMIs (24 upregulated and 8 
      downregulated) were identified in LSCC compared with normal controls. 502 
      negative correlations between DEMIs and DEMs were identified and subjected to 
      construct interaction network. In the network, hsa‑miR‑486, ‑34c, ‑206 and ‑182 
      had the highest connectivity with DEMs, and respectively regulated 39, 33, 28 and 
      27 DEMs. DEMs targeted by DEMIs were significantly enriched in signal 
      transduction, actin binding and extracellular region of GO terms and focal 
      adhesion and extracellular matrix‑receptor interaction of KEGG pathways. The 
      present study may provide valuable information for understanding the potential 
      oncogenesis mechanism in LSCC and provide the foundation work for diagnosis 
      biomarkers and therapeutic targets for LSCC.
FAU - Fei, Yonghua
AU  - Fei Y
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong 272000, P.R. China.
FAU - Guo, Ping
AU  - Guo P
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong 272000, P.R. China.
FAU - Wang, Fuling
AU  - Wang F
AD  - Department of Obstetrics, The First Maternity and Child Health Hospital of 
      Jining, Jining, Shandong 272000, P.R. China.
FAU - Li, Hu
AU  - Li H
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong 272000, P.R. China.
FAU - Lei, Yanhua
AU  - Lei Y
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong 272000, P.R. China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong 272000, P.R. China.
FAU - Xun, Xuehong
AU  - Xun X
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong 272000, P.R. China.
FAU - Lu, Fengxiang
AU  - Lu F
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Jining, Shandong 272000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170731
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Cluster Analysis
MH  - Down-Regulation/genetics
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Gene Ontology
MH  - Gene Regulatory Networks
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - MicroRNAs/*genetics/metabolism
MH  - Molecular Sequence Annotation
MH  - RNA, Messenger/genetics/metabolism
MH  - Signal Transduction/genetics
EDAT- 2017/08/03 06:00
MHDA- 2018/05/15 06:00
CRDT- 2017/08/03 06:00
PHST- 2016/10/19 00:00 [received]
PHST- 2017/06/06 00:00 [accepted]
PHST- 2017/08/03 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
PHST- 2017/08/03 06:00 [entrez]
AID - 10.3892/mmr.2017.7123 [doi]
PST - ppublish
SO  - Mol Med Rep. 2017 Oct;16(4):4179-4186. doi: 10.3892/mmr.2017.7123. Epub 2017 Jul 
      31.