PMID- 28766528
OWN - NLM
STAT- MEDLINE
DCOM- 20171130
LR  - 20171130
IS  - 0039-4521 (Print)
IS  - 0039-4521 (Linking)
VI  - 60
IP  - 4
DP  - 2017
TI  - [The importance of marker proteins of the nervous tissue for morphological 
      diagnostics of the craniocerebral injury].
PG  - 40-45
LID - 10.17116/sudmed201760440-45 [doi]
AB  - The present review of the literature involves 50 publications concerning various 
      substrates of importance as the biological markers of axonal damages with special 
      reference to the secondary molecular and cellular mechanisms on which to base in 
      vitro and in vivo modeling of the craniocerebral injury. The results of the 
      investigations with the application of mass-spectrometry for the identification 
      of the proteins specifically synthesized in response to the injury are presented; 
      their biological functions are described. The use of the sequential microscopic 
      imaging technique and the immunohistochemical methods made it possible to 
      determine that the majority of the marker proteins are involved in the specific 
      intracellular processes that are triggered in response to the traumatic impact 
      including apoptosis, proliferation, formation of lamellipodia, axon regeneration, 
      actin remodeling, cell migration and inflammation. In addition, a rise in the 
      amount of intracellular actin-associated proteins has been observed. It is 
      concluded that the investigations into the properties and the physiological role 
      of beta-amyloid precursor protein (beta-APP) are of special value for the 
      characteristic of nervous tissue damages and morphological diagnostics of the 
      craniocerebral injury.
FAU - Shai, A N
AU  - Shai AN
AD  - Russian Federal Centre of Forensic Medical Expertise, Ministry of Health of the 
      Russia, Moscow, Russia, 125284.
FAU - Fedulova, M V
AU  - Fedulova MV
AD  - Russian Federal Centre of Forensic Medical Expertise, Ministry of Health of the 
      Russia, Moscow, Russia, 125284.
FAU - Kvacheva, Yu E
AU  - Kvacheva YE
AD  - Russian Federal Centre of Forensic Medical Expertise, Ministry of Health of the 
      Russia, Moscow, Russia, 125284.
FAU - Shigeev, S V
AU  - Shigeev SV
AD  - Russian Federal Centre of Forensic Medical Expertise, Ministry of Health of the 
      Russia, Moscow, Russia, 125284.
FAU - Kovalev, A V
AU  - Kovalev AV
AD  - Russian Federal Centre of Forensic Medical Expertise, Ministry of Health of the 
      Russia, Moscow, Russia, 125284.
LA  - rus
PT  - Journal Article
PT  - Review
TT  - Znachenie belkov-markerov nervnoi tkani dlia morfologicheskoi diagnostiki 
      cherepno-mozgovoi travmy.
PL  - Russia (Federation)
TA  - Sud Med Ekspert
JT  - Sudebno-meditsinskaia ekspertiza
JID - 0404546
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Biomarkers)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*analysis
MH  - Biomarkers/analysis
MH  - *Craniocerebral Trauma/diagnosis/metabolism
MH  - Forensic Medicine/*methods
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Mass Spectrometry/methods
MH  - Nerve Tissue Proteins/*analysis
OTO - NOTNLM
OT  - beta-APP
OT  - biological markers
OT  - diffuse axonal damage
OT  - immunohistochemical studies
OT  - morphological diagnostics of the craniocerebral injury
EDAT- 2017/08/03 06:00
MHDA- 2017/12/01 06:00
CRDT- 2017/08/03 06:00
PHST- 2017/08/03 06:00 [entrez]
PHST- 2017/08/03 06:00 [pubmed]
PHST- 2017/12/01 06:00 [medline]
AID - 10.17116/sudmed201760440-45 [doi]
PST - ppublish
SO  - Sud Med Ekspert. 2017;60(4):40-45. doi: 10.17116/sudmed201760440-45.