PMID- 2876684
OWN - NLM
STAT- MEDLINE
DCOM- 19861119
LR  - 20131121
IS  - 0003-9780 (Print)
IS  - 0003-9780 (Linking)
VI  - 282
IP  - 1
DP  - 1986 Jul
TI  - Regional hemodynamic effects of the beta-adrenoceptor blockers tertatolol and 
      propranolol in conscious spontaneously hypertensive rats.
PG  - 118-29
AB  - The effects of the beta-adrenoceptor blocking drugs propranolol and tertatolol on 
      regional hemodynamics were studied in conscious spontaneously hypertensive rats 
      (SHR). Regional blood flows were measured using a 20 MHz directional pulsed 
      Doppler system with miniaturized Doppler probes on the left renal artery, the 
      superior mesenteric artery and the abdominal aorta. This allowed the 
      determination of changes in resistances in the renal (RR), mesenteric (MR) and 
      hindquarter (HQR) vascular beds. Tertatolol and propranolol caused an immediate 
      fall in heart rate. Mean arterial pressure (MAP) increased during the first 15-30 
      min following injection of the beta-blockers. Thereafter it gradually fell below 
      control values to reach significant decreases in MAP 3-4 hr following injection. 
      Fifteen to thirty min after propranolol, vascular resistances increased in all 3 
      vascular beds significantly. Resistances returned to control values over the next 
      3-4 hr. Following tertatolol, HQR increased significantly during the first 15-30 
      min. MR and RR did not increase significantly whereas a significant fall in RR 
      was observed after 3-4 hr. These data indicate different regional hemodynamic 
      effects for tertatolol and propranolol in the conscious SHR. Tertatolol does not 
      cause the renal and mesenteric vaso-constriction observed following propranolol.
FAU - Nievelstein, H M
AU  - Nievelstein HM
FAU - Tijssen, C M
AU  - Tijssen CM
FAU - Smits, J F
AU  - Smits JF
FAU - Struyker-Boudier, H A
AU  - Struyker-Boudier HA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Belgium
TA  - Arch Int Pharmacodyn Ther
JT  - Archives internationales de pharmacodynamie et de therapie
JID - 0405353
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Propanolamines)
RN  - 0 (Thiophenes)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - 9ZO341YQXP (tertatolol)
SB  - IM
MH  - Adrenergic beta-Antagonists/*pharmacology
MH  - Animals
MH  - Heart Rate/drug effects
MH  - Hemodynamics/*drug effects
MH  - Hindlimb/blood supply
MH  - Male
MH  - Propanolamines/*pharmacology
MH  - Propranolol/*pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Regional Blood Flow/drug effects
MH  - Renal Circulation/drug effects
MH  - *Thiophenes
MH  - Vascular Resistance/drug effects
EDAT- 1986/07/01 00:00
MHDA- 1986/07/01 00:01
CRDT- 1986/07/01 00:00
PHST- 1986/07/01 00:00 [pubmed]
PHST- 1986/07/01 00:01 [medline]
PHST- 1986/07/01 00:00 [entrez]
PST - ppublish
SO  - Arch Int Pharmacodyn Ther. 1986 Jul;282(1):118-29.