PMID- 28768084
OWN - NLM
STAT- MEDLINE
DCOM- 20171207
LR  - 20191113
IS  - 1066-2936 (Print)
IS  - 1066-2936 (Linking)
VI  - 44
IP  - 1
DP  - 2017 Jan-Feb
TI  - Changes in angiotensin II and angiotensin-converting enzyme of different tissues 
      after prolonged hyperoxia exposure.
PG  - 39-44
AB  - Current study findings concerning changes in the renin-angiotensin system (RAS) 
      in cases of hyperoxic acute lung injury (HALI) have shown conflicting results. 
      This study aimed to detect the angiotensin II (Ang II) and angiotensin-converting 
      enzyme (ACE) in a rat HALI model. Healthy male Sprague-Dawley rats were randomly 
      assigned into three groups: the control group, HALI group and hyperbaric oxygen 
      preconditioning (HBO(2)-PC) group. HALI was induced by exposure to pure oxygen at 
      250 kPa for six hours. In the HBO(2)-PC group, rats were exposed to oxygen at 250 
      kPa for 60 minutes twice daily for two consecutive days; HALI was induced at 24 
      hours after the last oxygen exposure.=After HALI, the lung, spleen and liver were 
      harvested for HE staining and pathological examination. At one hour and 18 hours 
      after HALI, the blood, liver, lung and spleen were collected for the detection of 
      Ang II and ACE contents by enzyme-linked immunosorbent assay. Pathological 
      examination showed the lung was significantly damaged and characteristics of HALI 
      were observed, but there were no significant pathological changes in the liver 
      and spleen. After HALI, Ang II and ACE contents of different tissues increased 
      progressively over time, but the HBO(2)-PC group showed reductions in the Ang II 
      and ACE contents to a certain extent, especially at 18 hours after injury. These 
      findings suggest prolonged hyperoxia exposure may activate the RAS, which may be 
      associated with the pathogenesis of HALI. HBO(2)-PC has a limited capability to 
      inhibit RAS activation.
CI  - Copyright(c) Undersea and Hyperbaric Medical Society.
FAU - Han, Cui-Hong
AU  - Han CH
AD  - Department of Pathology, the First People?s Hospital of Jining City, No 6, 
      Jiankang Road, Jining City, Shandong, 272011, P. R. China.
FAU - Zhang, Pei-Xi
AU  - Zhang PX
AD  - Department of Cardiothoracic Surgery, the First People?s Hospital of Jining City, 
      No 6, Jiankang Road, Jining City, Shandong, 272011, P. R. China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Pathology, Yantaishan Hospital, No 91, Jiefang Road, Zhifu 
      District, Yantai City, Shandong, 264001, P. R. China.
FAU - Zheng, Juan
AU  - Zheng J
AD  - Department Diving and Hyperbaric Medicine, Secondary Military Medical University, 
      No 800, Xiangyin Road, Yangpu District, Shanghai, 200433, P. R. China.
FAU - Liu, Kan
AU  - Liu K
AD  - Department Diving and Hyperbaric Medicine, Secondary Military Medical University, 
      No 800, Xiangyin Road, Yangpu District, Shanghai, 200433, P. R. China.
FAU - Wei, Dunbiao
AU  - Wei D
AD  - Department Diving and Hyperbaric Medicine, Secondary Military Medical University, 
      No 800, Xiangyin Road, Yangpu District, Shanghai, 200433, P. R. China.
FAU - Qiao, Tongju
AU  - Qiao T
AD  - Department Diving and Hyperbaric Medicine, Secondary Military Medical University, 
      No 800, Xiangyin Road, Yangpu District, Shanghai, 200433, P. R. China.
FAU - Peng, Bo
AU  - Peng B
AD  - Department Diving and Hyperbaric Medicine, Secondary Military Medical University, 
      No 800, Xiangyin Road, Yangpu District, Shanghai, 200433, P. R. China.
FAU - Liu, Wenwu
AU  - Liu W
AD  - Department Diving and Hyperbaric Medicine, Secondary Military Medical University, 
      No 800, Xiangyin Road, Yangpu District, Shanghai, 200433, P. R. China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Undersea Hyperb Med
JT  - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical 
      Society, Inc
JID - 9312954
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Acute Lung Injury
MH  - Angiotensin II/*analysis/blood
MH  - Animals
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hyperbaric Oxygenation
MH  - Hyperoxia/complications/*metabolism
MH  - Liver/*chemistry
MH  - Lung/*chemistry/pathology
MH  - Male
MH  - Oxygen/*adverse effects
MH  - Peptidyl-Dipeptidase A/*analysis/blood
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Renin-Angiotensin System
MH  - Spleen/*chemistry
MH  - Time Factors
OTO - NOTNLM
OT  - angiotensin II
OT  - angiotensin-converting enzyme
OT  - hyperoxic acute lung injury
OT  - renin-angiotensin system
COIS- The authors of this paper declare no conflicts of interest exist with this 
      submission.
EDAT- 2017/08/03 06:00
MHDA- 2017/12/08 06:00
CRDT- 2017/08/03 06:00
PHST- 2017/08/03 06:00 [entrez]
PHST- 2017/08/03 06:00 [pubmed]
PHST- 2017/12/08 06:00 [medline]
AID - 10.22462/1.2.2017.7 [doi]
PST - ppublish
SO  - Undersea Hyperb Med. 2017 Jan-Feb;44(1):39-44. doi: 10.22462/1.2.2017.7.