PMID- 28768996
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20180502
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 40
IP  - 8
DP  - 2017
TI  - Functional Expression of Organic Ion Transporters in Astrocytes and Their 
      Potential as a Drug Target in the Treatment of Central Nervous System Diseases.
PG  - 1153-1160
LID - 10.1248/bpb.b17-00076 [doi]
AB  - It has become widely acknowledged that astrocytes play essential roles in 
      maintaining physiological central nervous system (CNS) activities. Astrocytes 
      fulfill their roles partly through the manipulation of their plasma membrane 
      transporter functions, and therefore these transporters have been regarded as 
      promising drug targets for various CNS diseases. A representative example is 
      excitatory amino acid transporter 2 (EAAT2), which works as a critical regulator 
      of excitatory signal transduction through its glutamate uptake activity at the 
      tripartite synapse. Thus, enhancement of EAAT2 functionality is expected to 
      accelerate glutamate clearance at synapses, which is a promising approach for the 
      prevention of over-excitation of glutamate receptors. In addition to such 
      well-known astrocyte-specific transporters, cumulative evidence suggests that 
      multi-specific organic ion transporters (i.e., organic cation/anion transporters 
      [OCTs/OATs], carnitine/organic cation transporters [OCTNs], and organic anion 
      transporting polypeptides [OATPs]) are also functionally expressed in astrocytes. 
      Even though identification and characterization of their 
      physiological/pathophysiological roles in astrocytes are in the initial stage, 
      the findings obtained so far indicate that OCT3 and plasma membrane monoamine 
      transporter are significantly involved in the clearance of biogenic amine 
      neurotransmitters in the synaptic cleft, and that OCTN2 and OATP1C1 provide a 
      cellular entry gate for carnitine/acetyl-L-carnitine and thyroxine, respectively. 
      Therefore, organic ion transporters, including those mentioned above, are 
      expected to become emerging pharmacological targets for various CNS diseases. 
      With such expectations in mind, this review will briefly summarize the functional 
      expression of organic ion transporters in astrocytes.
FAU - Furihata, Tomomi
AU  - Furihata T
AD  - Department of Pharmacology, Graduate School of Medicine, Chiba University.
AD  - Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical 
      Sciences, Chiba University.
FAU - Anzai, Naohiko
AU  - Anzai N
AD  - Department of Pharmacology, Graduate School of Medicine, Chiba University.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Organic Anion Transporters)
RN  - 0 (Organic Cation Transport Proteins)
SB  - IM
MH  - Animals
MH  - Astrocytes/*metabolism
MH  - Central Nervous System Diseases/drug therapy/*metabolism
MH  - Humans
MH  - Organic Anion Transporters/*metabolism
MH  - Organic Cation Transport Proteins/*metabolism
OTO - NOTNLM
OT  - astrocyte
OT  - central nervous system
OT  - drug development
OT  - transporter
EDAT- 2017/08/05 06:00
MHDA- 2018/05/03 06:00
CRDT- 2017/08/04 06:00
PHST- 2017/08/04 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
AID - 10.1248/bpb.b17-00076 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2017;40(8):1153-1160. doi: 10.1248/bpb.b17-00076.