PMID- 28769008
OWN - NLM
STAT- MEDLINE
DCOM- 20180502
LR  - 20180502
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 40
IP  - 8
DP  - 2017
TI  - Ketamine Alleviates Depressive-Like Behaviors via Down-Regulating Inflammatory 
      Cytokines Induced by Chronic Restraint Stress in Mice.
PG  - 1260-1267
LID - 10.1248/bpb.b17-00131 [doi]
AB  - The purpose of the present study was to investigate whether ketamine's rapid 
      antidepressant effects were associated with its anti-inflammatory actions and to 
      explore the underlying molecular mechanism. Depressive-like behaviors was induced 
      in mice using chronic restraint stress (CRS) method. Anti-depressive effects of 
      ketamine were evaluated by forced swimming tests (FST) and sucrose preference 
      test (SPT). Subsequently, brain tissue was harvested to investigate inflammatory 
      response in the hippocampus via investigating reactive microglia numbers, serum 
      cytokines levels and the toll-like receptor type 4 (TLR4)/p38 mitogen-activated 
      protein kinase (MAPK) pathway. CRS exposure caused depressive-like behaviors in 
      mice, which was associated with increased pre-inflammatory cytokines (interleukin 
      (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-6) levels, reactive microglia 
      numbers and up-regulated regulatory molecules such as TLR4/p38 and P2X7 receptor 
      in hippocampus. Such neurobehavioral and biochemical abnormalities were 
      normalized by ketamine treatment. CRS-induced depression-like behaviours are 
      associated with activation of hippocampal inflammatory response, whereas 
      down-regulation of pro-inflammatory cytokines may contribute to ketamine's 
      antidepressant effects in mice.
FAU - Tan, Sijie
AU  - Tan S
AD  - Department of Histology and Embryology, School of Medicine, University of South 
      China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Histology and Embryology, School of Medicine, University of South 
      China.
FAU - Chen, Ke
AU  - Chen K
AD  - Department of Ultrasound Diagnosis, Affiliated Nanhua Hospital, University of 
      South China.
FAU - Long, Zhifeng
AU  - Long Z
AD  - Department of Histology and Embryology, School of Medicine, University of South 
      China.
FAU - Zou, Ju
AU  - Zou J
AD  - Department of Parasitology, School of Medicine, University of South China.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Antidepressive Agents)
RN  - 0 (Cytokines)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, Purinergic P2X7)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 4)
RN  - 57-50-1 (Sucrose)
RN  - 690G0D6V8H (Ketamine)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Corticosterone/blood
MH  - Cytokines/metabolism
MH  - Down-Regulation/drug effects
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Food Preferences
MH  - Hippocampus/drug effects/metabolism
MH  - Ketamine/*pharmacology
MH  - Mice
MH  - Receptors, Purinergic P2X7/metabolism
MH  - Restraint, Physical/adverse effects
MH  - Stress, Psychological/blood/*metabolism
MH  - Sucrose
MH  - Swimming
MH  - Toll-Like Receptor 4/metabolism
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
OTO - NOTNLM
OT  - P2X7
OT  - depression
OT  - inflammation
OT  - ketamine
OT  - toll-like receptor type 4 (TLR4)
EDAT- 2017/08/05 06:00
MHDA- 2018/05/03 06:00
CRDT- 2017/08/04 06:00
PHST- 2017/08/04 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2018/05/03 06:00 [medline]
AID - 10.1248/bpb.b17-00131 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2017;40(8):1260-1267. doi: 10.1248/bpb.b17-00131.