PMID- 28769766
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 11
DP  - 2017
TI  - Breakthrough Cancer Pain Is Associated with Spinal Gap Junction Activation via 
      Regulation of Connexin 43 in a Mouse Model.
PG  - 207
LID - 10.3389/fncel.2017.00207 [doi]
LID - 207
AB  - Breakthrough cancer pain (BTcP) is a high-intensity, short-duration, 
      unpredictable and uncontrollable pain. Recent studies have shown that activation 
      of gap junction (GJ) in spinal cord plays an important role in the pathogenesis 
      of BTcP. We examined the expressions of Glial fibrillary acidic protein (GFAP), 
      connexin (Cx) 43 protein and phosphorylation of Cx43 (p-Cx43) in the spinal cord 
      of mice. In addition, we investigated the effects of Gap26, a selective GJ 
      blocker, on the expressions of GFAP, Cx43 and p-Cx43 in BTcP mice. We found that 
      the expressions of GFAP and Cx43 proteins were significantly upregulated while 
      p-Cx43 was down-regulated in the spinal cord in a mouse model of BTcP. The 
      overexpression of Cx43 protein in the spinal cord increased GJ formation and 
      enhanced BTcP. The variation of the ratio of p-Cx43/T-Cx43 (total Cx43) affected 
      the function of GJ to induce BTcP. Furthermore, BTcP was alleviated by Gap26 via 
      reducing pain hypersensitivity. The inhibition of Cx43 and p-Cx43 by Gap26 
      attenuated BTcP but the p/T ratio of Cx43 remained unchanged in BTcP mice. We 
      reveal that the expression and phosphorylation of Cx43 affected BTcP and GJ 
      activation facilitated BTcP via a Cx43-mediated signaling in the spinal cord. The 
      finding may provide a scientific rationale for discovery and development of novel 
      therapeutic targets for the treatment of BTcP clinically.
FAU - Li, Xin
AU  - Li X
AD  - Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, 
      Central South UniversityChangsha, China.
FAU - Jiang, Siqing
AU  - Jiang S
AD  - Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, 
      Central South UniversityChangsha, China.
FAU - Yang, Hui
AU  - Yang H
AD  - Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, 
      Central South UniversityChangsha, China.
FAU - Liao, Qian
AU  - Liao Q
AD  - Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, 
      Central South UniversityChangsha, China.
FAU - Cao, Shousong
AU  - Cao S
AD  - Department of Pharmacology, School of Pharmacy, Southwest Medical 
      UniversityLuzhou, China.
FAU - Yan, Xuebin
AU  - Yan X
AD  - Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, 
      Central South UniversityChangsha, China.
FAU - Huang, Dong
AU  - Huang D
AD  - Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, 
      Central South UniversityChangsha, China.
LA  - eng
PT  - Journal Article
DEP - 20170717
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC5511832
OTO - NOTNLM
OT  - Gap26
OT  - breakthrough cancer pain
OT  - connexin 43
OT  - gap junction
OT  - phosphorylation
OT  - spinal cord
EDAT- 2017/08/05 06:00
MHDA- 2017/08/05 06:01
PMCR- 2017/01/01
CRDT- 2017/08/04 06:00
PHST- 2017/04/25 00:00 [received]
PHST- 2017/06/30 00:00 [accepted]
PHST- 2017/08/04 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2017/08/05 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2017.00207 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2017 Jul 17;11:207. doi: 10.3389/fncel.2017.00207. 
      eCollection 2017.