PMID- 28769852
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-1078 (Print)
IS  - 1664-1078 (Electronic)
IS  - 1664-1078 (Linking)
VI  - 8
DP  - 2017
TI  - Loneliness in Relation to Depression: The Moderating Influence of a Polymorphism 
      of the Brain Derived Neurotrophic Factor Gene on Self-efficacy and Coping 
      Strategies.
PG  - 1224
LID - 10.3389/fpsyg.2017.01224 [doi]
LID - 1224
AB  - Disturbances of brain derived neurotrophic factor (BDNF) signaling, which may 
      occur among those with a polymorphism of the Val66Met gene, comprising a Met 
      substitution for the Val allele, may be associated with depressive cognitions. 
      However, presumed elevated BDNF levels among individuals with the Val/Val 
      genotype, might confer increased responsivity to contextual challenges, thus 
      fostering vulnerability to depression. In Study 1, among undergraduate students 
      (N = 252), increased loneliness perceptions were accompanied with depressive 
      symptoms. This relationship was moderated by self-efficacy and BDNF genotype, 
      such that when individuals appraised high self-efficacy, those with the Val/Val 
      genotype, compared to Met carriers, reported greater depression scores when they 
      perceived feeling lonely. Study 2 revealed that among undergraduate students (N = 
      178), lower depressive scores were associated with increased problem-focused 
      coping among Val/Val individuals, but not Met carriers. Moreover, with increased 
      perceived loneliness, Val/Val carriers endorsed lower problem-focused coping. 
      Findings suggest that Val/Val individuals may have adverse neurocognitive 
      vulnerability to loneliness experiences.
FAU - Bedard, Marc
AU  - Bedard M
AD  - Department of Neuroscience, Carleton UniversityOttawa, ON, Canada.
FAU - Woods, Robbie
AU  - Woods R
AD  - Department of Neuroscience, Carleton UniversityOttawa, ON, Canada.
FAU - Crump, Carly
AU  - Crump C
AD  - Department of Neuroscience, Carleton UniversityOttawa, ON, Canada.
FAU - Anisman, Hymie
AU  - Anisman H
AD  - Department of Neuroscience, Carleton UniversityOttawa, ON, Canada.
LA  - eng
PT  - Journal Article
DEP - 20170719
PL  - Switzerland
TA  - Front Psychol
JT  - Frontiers in psychology
JID - 101550902
PMC - PMC5515873
OTO - NOTNLM
OT  - brain derived neurotrophic factor
OT  - coping
OT  - depression
OT  - polymorphism
OT  - self-efficacy
OT  - single nucleotide
EDAT- 2017/08/05 06:00
MHDA- 2017/08/05 06:01
PMCR- 2017/07/19
CRDT- 2017/08/04 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/07/04 00:00 [accepted]
PHST- 2017/08/04 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2017/08/05 06:01 [medline]
PHST- 2017/07/19 00:00 [pmc-release]
AID - 10.3389/fpsyg.2017.01224 [doi]
PST - epublish
SO  - Front Psychol. 2017 Jul 19;8:1224. doi: 10.3389/fpsyg.2017.01224. eCollection 
      2017.