PMID- 28770105
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2056-4538 (Print)
IS  - 2056-4538 (Electronic)
IS  - 2056-4538 (Linking)
VI  - 3
IP  - 3
DP  - 2017 Jul
TI  - Multi-parametric profiling of renal cell, colorectal, and ovarian cancer 
      identifies tumour-type-specific stroma phenotypes and a novel vascular biomarker.
PG  - 214-224
LID - 10.1002/cjp2.74 [doi]
AB  - A novel set of integrated procedures for quantification of fibroblast-rich stroma 
      and vascular characteristics has recently been presented allowing discovery of 
      novel perivascular and stromal biomarkers in colorectal, renal cell, and ovarian 
      cancer. In the present study, data obtained through these procedures from 
      clinically well-annotated collections of these three tumour types have been used 
      to address two novel questions. First, data have been used to investigate if the 
      three tumour types demonstrate significant differences regarding features such as 
      vessel diameter, vessel density, and perivascular marker expression. Second, 
      analyses of the cohorts have been used to explore the prognostic significance of 
      a novel vascular metric, 'vessel distance inter-quartile range (IQR)' that 
      describes intra-case heterogeneity regarding vessel distribution. The comparisons 
      between the three tumour types demonstrated a set of significant differences. 
      Vessel density of renal cell cancer was statistically significantly higher than 
      in colorectal and ovarian cancer. Vessel diameter was statistically significantly 
      higher in ovarian cancer. Concerning perivascular status, colorectal cancer 
      displayed significantly higher levels of perivascular PDGFR-beta expression than the 
      other two tumour types. Intra-case heterogeneity of perivascular PDGFR-beta 
      expression was also higher in colorectal cancer. Notably, these 
      fibroblast-dominated stroma phenotypes matched previously described experimental 
      tumour stroma characteristics, which have been linked to differential sensitivity 
      to anti-VEGF drugs. High 'vessel distance IQR' was significantly associated with 
      poor survival in both renal cell cancer and colorectal cancer. In renal cell 
      cancer, this characteristic also acted as an independent prognostic marker 
      according to multivariate analyses including standard clinico-pathological 
      characteristics. Explorative subset analyses indicated particularly strong 
      prognostic significance of 'vessel distance IQR' in T stage 4 of this cancer 
      type. Together, these analyses identified tumour-type-specific vascular-stroma 
      phenotypes of possible functional significance, and suggest 'vessel distance IQR' 
      as a novel prognostic biomarker.
FAU - Corvigno, Sara
AU  - Corvigno S
AUID- ORCID: 0000-0001-5458-2243
AD  - Department of Oncology-PathologyKarolinska InstitutetStockholmSweden.
FAU - Frodin, Magnus
AU  - Frodin M
AD  - Department of Oncology-PathologyKarolinska InstitutetStockholmSweden.
FAU - Wisman, G Bea A
AU  - Wisman GBA
AD  - Department of Gynecologic OncologyUniversity of Groningen, University Medical 
      Center GroningenGroningenThe Netherlands.
FAU - Nijman, Hans W
AU  - Nijman HW
AD  - Department of Gynecologic OncologyUniversity of Groningen, University Medical 
      Center GroningenGroningenThe Netherlands.
FAU - Van der Zee, Ate Gj
AU  - Van der Zee AG
AD  - Department of Gynecologic OncologyUniversity of Groningen, University Medical 
      Center GroningenGroningenThe Netherlands.
FAU - Jirstrom, Karin
AU  - Jirstrom K
AD  - Department of Clinical Sciences, Division of Oncology and PathologyLund 
      UniversityLundSweden.
FAU - Nodin, Bjorn
AU  - Nodin B
AD  - Department of Clinical Sciences, Division of Oncology and PathologyLund 
      UniversityLundSweden.
FAU - Hrynchyk, Ina
AU  - Hrynchyk I
AD  - City Clinical Pathologoanatomic BureauMinskBelarus.
FAU - Edler, David
AU  - Edler D
AD  - Department of Molecular Medicine and SurgeryKarolinska University Hospital 
      SolnaStockholmSweden.
FAU - Ragnhammar, Peter
AU  - Ragnhammar P
AD  - Department of Oncology-PathologyKarolinska InstitutetStockholmSweden.
FAU - Johansson, Martin
AU  - Johansson M
AUID- ORCID: 0000-0001-8510-3102
AD  - Department of Laboratory MedicineSkanes UniversitetssjukhusMalmo.
FAU - Dahlstrand, Hanna
AU  - Dahlstrand H
AD  - Department of Oncology-PathologyKarolinska InstitutetStockholmSweden.
AD  - Department of OncologyUppsala University HospitalUppsalaSweden.
FAU - Mezheyeuski, Artur
AU  - Mezheyeuski A
AD  - Department of Oncology-PathologyKarolinska InstitutetStockholmSweden.
AD  - Department of Immunology, Genetics and PathologyUppsala UniversityUppsalaSweden.
FAU - Ostman, Arne
AU  - Ostman A
AD  - Department of Oncology-PathologyKarolinska InstitutetStockholmSweden.
LA  - eng
PT  - Journal Article
DEP - 20170724
PL  - England
TA  - J Pathol Clin Res
JT  - The journal of pathology. Clinical research
JID - 101658534
PMC - PMC5527322
OTO - NOTNLM
OT  - PDGFR-beta
OT  - colorectal cancer
OT  - ovarian cancer
OT  - pericytes
OT  - renal cell cancer
OT  - survival
OT  - tumour microenvironment
OT  - vessels
EDAT- 2017/08/05 06:00
MHDA- 2017/08/05 06:01
PMCR- 2017/07/24
CRDT- 2017/08/04 06:00
PHST- 2017/02/13 00:00 [received]
PHST- 2017/06/08 00:00 [accepted]
PHST- 2017/08/04 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2017/08/05 06:01 [medline]
PHST- 2017/07/24 00:00 [pmc-release]
AID - CJP274 [pii]
AID - 10.1002/cjp2.74 [doi]
PST - epublish
SO  - J Pathol Clin Res. 2017 Jul 24;3(3):214-224. doi: 10.1002/cjp2.74. eCollection 
      2017 Jul.