PMID- 28770106
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2017
DP  - 2017
TI  - Outcome of Surgical Treatment in Late-Onset Capsular Block Syndrome.
PG  - 1847179
LID - 10.1155/2017/1847179 [doi]
LID - 1847179
AB  - PURPOSE: To further investigate the pathogenesis of late-onset capsular block 
      syndrome (CBS) and to evaluate the safety of surgical treatment. METHODS: Seven 
      patients diagnosed with late-onset CBS were retrospectively analyzed. Anterior 
      chamber depth (ACD), intraocular pressure (IOP), refractive diopter, and 
      best-corrected visual acuity (BCVA) before and after surgery were recorded. The 
      opaque substance was tested with Western blot, and a flow cytometer multiple 
      array assay system was utilized to evaluate the levels of inflammatory cytokines 
      from opaque substance and aqueous humor, respectively. RESULTS: Patients who had 
      undergone surgical treatment showed a significant BCVA and spherical equivalent 
      refractive error improvement (P = 0.002, P = 0.021, resp.). Nevertheless, ACD and 
      IOP before and after surgery were in normal range with no difference (P = 0.165, 
      P = 0.749, resp.). alphaB-crystallin and betaB-crystallin were detected in all opaque 
      substances. Tumor necrosis factor-alpha (TNF-alpha) and interlukin-1beta (IL-1beta) levels 
      in opaque substance were significantly higher than those in aqueous humor (P = 
      0.038, P = 0.007, resp.), while IL-2 and IL-6 were not detected in any samples. 
      CONCLUSIONS: Opaque substance is derived from human lens epithelial cells. 
      Inflammatory cytokines may be involved in the pathogenesis of late-onset CBS. In 
      addition, surgical treatment is an effective approach. This trial is registered 
      with ChiCTR-IOR-17011287.
FAU - Huang, Yang
AU  - Huang Y
AUID- ORCID: 0000-0002-2634-3234
AD  - Department of Ophthalmology, The Chinese People's Liberation Army General 
      Hospital, Beijing, China.
FAU - Ye, Zi
AU  - Ye Z
AD  - Department of Ophthalmology, The Chinese People's Liberation Army General 
      Hospital, Beijing, China.
FAU - Li, Hang
AU  - Li H
AD  - Medical Department, The First Hospital Affiliated to General Hospital of the 
      Chinese People's Liberation Army, Beijing, China.
FAU - Li, Zhaohui
AU  - Li Z
AUID- ORCID: 0000-0003-3850-5971
AD  - Department of Ophthalmology, The Chinese People's Liberation Army General 
      Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20170709
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC5523514
EDAT- 2017/08/05 06:00
MHDA- 2017/08/05 06:01
PMCR- 2017/07/09
CRDT- 2017/08/04 06:00
PHST- 2017/01/15 00:00 [received]
PHST- 2017/04/03 00:00 [revised]
PHST- 2017/04/18 00:00 [accepted]
PHST- 2017/08/04 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2017/08/05 06:01 [medline]
PHST- 2017/07/09 00:00 [pmc-release]
AID - 10.1155/2017/1847179 [doi]
PST - ppublish
SO  - J Ophthalmol. 2017;2017:1847179. doi: 10.1155/2017/1847179. Epub 2017 Jul 9.