PMID- 28770438
OWN - NLM
STAT- MEDLINE
DCOM- 20180626
LR  - 20211204
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 42
IP  - 11
DP  - 2017 Nov
TI  - Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic 
      Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed 
      Mice.
PG  - 3149-3159
LID - 10.1007/s11064-017-2353-2 [doi]
AB  - In the present study, we investigated the concentration-dependent effect of zinc 
      (Zn) supplementation on the adult hippocampus in a high-fat diet (HFD)-fed obese 
      mouse model. Four-weeks after HFD- and control diet (CD)-feeding, mice were 
      provided with low (15 ppm) or high (60 ppm) doses of Zn in their drinking water 
      for additional 4 more weeks along with their respective diets. Compared to the 
      CD-fed mice, HFD-feeding elicited the reduction of neurogenic markers such as 
      nestin, Ki67, doublecortin (DCX), and 5-bromo-2'-deoxyuridine (BrdU) in the 
      dentate gyrus. Additionally, HFD-feeding reduced the levels of synaptic markers 
      (synaptophysin and N-methyl-D-aspartate receptor) and brain-derived neurotrophic 
      factor (BDNF), while lipid peroxidation was significantly increased in the 
      hippocampus of HFD-fed mice. Against detrimental effects of high-dose Zn, 
      low-dose Zn supplementation in CD-fed mice did not yield any remarkable changes 
      in these parameters. Interestingly, administration of low doses of Zn to 
      HFD-induced obese mice prominently ameliorated HFD-induced changes in neurogenic, 
      synaptic plasticity markers and BDNF levels as well as lipid peroxidation in the 
      hippocampus. In contrast, high-dose Zn supplementation in HFD-fed mice 
      exacerbated the reduction of markers for neurogenesis and synaptic plasticity as 
      well as BDNF levels, but not 4-HNE levels, in the hippocampus. These results 
      suggest that low-dose Zn supplementation in obese mice could reverse the 
      HFD-induced reduction in neurogenic and synaptic marker proteins in the 
      hippocampus by reducing lipid peroxidation and improving BDNF expression, while 
      high-dose Zn supplementation exacerbates the reduction of neurogenesis by 
      affecting synaptic markers and BDNF levels in the hippocampus.
FAU - Nam, Sung Min
AU  - Nam SM
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine, and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      08826, South Korea.
AD  - Department of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul, 
      05030, South Korea.
FAU - Kim, Jong Whi
AU  - Kim JW
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine, and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      08826, South Korea.
FAU - Kwon, Hyun Jung
AU  - Kwon HJ
AD  - Department of Biochemistry and Molecular Biology, Research Institute of Oral 
      Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, 
      25457, South Korea.
FAU - Yoo, Dae Young
AU  - Yoo DY
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine, and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      08826, South Korea.
FAU - Jung, Hyo Young
AU  - Jung HY
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine, and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      08826, South Korea.
FAU - Kim, Dae Won
AU  - Kim DW
AD  - Department of Biochemistry and Molecular Biology, Research Institute of Oral 
      Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, 
      25457, South Korea.
FAU - Hwang, In Koo
AU  - Hwang IK
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine, and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      08826, South Korea.
AD  - KMPC (Korea Mouse Phenotyping Center), Seoul National University, Seoul, 08826, 
      South Korea.
FAU - Seong, Je Kyung
AU  - Seong JK
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine, and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      08826, South Korea.
AD  - KMPC (Korea Mouse Phenotyping Center), Seoul National University, Seoul, 08826, 
      South Korea.
FAU - Yoon, Yeo Sung
AU  - Yoon YS
AD  - Department of Anatomy and Cell Biology, College of Veterinary Medicine, and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      08826, South Korea. ysyoon@snu.ac.kr.
AD  - KMPC (Korea Mouse Phenotyping Center), Seoul National University, Seoul, 08826, 
      South Korea. ysyoon@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20170802
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Dcx protein, mouse)
RN  - 0 (Doublecortin Protein)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Diet, High-Fat/*adverse effects
MH  - *Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Doublecortin Protein
MH  - Hippocampus/drug effects/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurogenesis/drug effects/*physiology
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Zinc/*administration & dosage
OTO - NOTNLM
OT  - BDNF
OT  - High-fat diet
OT  - Lipid peroxidation
OT  - Neurogenesis
OT  - Synaptic proteins
OT  - Zinc
EDAT- 2017/08/05 06:00
MHDA- 2018/06/27 06:00
CRDT- 2017/08/04 06:00
PHST- 2017/03/17 00:00 [received]
PHST- 2017/07/10 00:00 [accepted]
PHST- 2017/06/13 00:00 [revised]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2018/06/27 06:00 [medline]
PHST- 2017/08/04 06:00 [entrez]
AID - 10.1007/s11064-017-2353-2 [pii]
AID - 10.1007/s11064-017-2353-2 [doi]
PST - ppublish
SO  - Neurochem Res. 2017 Nov;42(11):3149-3159. doi: 10.1007/s11064-017-2353-2. Epub 
      2017 Aug 2.