PMID- 28771459
OWN - NLM
STAT- MEDLINE
DCOM- 20170808
LR  - 20181113
IS  - 1545-861X (Electronic)
IS  - 0149-2195 (Print)
IS  - 0149-2195 (Linking)
VI  - 66
IP  - 30
DP  - 2017 Aug 4
TI  - Solid Organ Transplant-Transmitted Tuberculosis Linked to a Community Outbreak - 
      California, 2015.
PG  - 801-805
LID - 10.15585/mmwr.mm6630a1 [doi]
AB  - In the spring of 2015, a local health department (LHD) in county A notified the 
      California Department of Public Health (CDPH) about three adults with close ties 
      to one another and a congregate community site who had received diagnoses of 
      tuberculosis (TB) disease within a 3-month period. Subsequent review revealed 
      matching TB genotypes indicating that the cases were likely part of a chain of TB 
      transmission. Only three TB cases in California in the preceding 2 years shared 
      this same genotype. One of those three previous cases occurred in a 
      lung-transplant recipient who had no identified epidemiologic links to the 
      outbreak. CDPH, multiple LHDs, and CDC conducted an investigation and determined 
      that the lung-transplant donor (patient 1) was epidemiologically linked to the 
      three outbreak cases and had a tuberculin skin test (TST) conversion detected in 
      2012 upon reentry at a local jail. Three other solid organ recipients from this 
      donor were identified; none had developed TB disease. This investigation suggests 
      that review of organ donors' medical records from high-risk environments, such as 
      jails, might reveal additional information about TB risk. The evaluation of TB in 
      organ recipients could include genotyping analysis (1) and coordination among 
      local, state, and national partners to evaluate the potential for donor-derived 
      TB.
FAU - Kay, Alexander
AU  - Kay A
FAU - Barry, Pennan M
AU  - Barry PM
FAU - Annambhotla, Pallavi
AU  - Annambhotla P
FAU - Greene, Carol
AU  - Greene C
FAU - Cilnis, Martin
AU  - Cilnis M
FAU - Chin-Hong, Peter
AU  - Chin-Hong P
FAU - Arger, Nicholas
AU  - Arger N
FAU - McNitt, Louise
AU  - McNitt L
FAU - Neidlinger, Nikole
AU  - Neidlinger N
FAU - Shah, Neha
AU  - Shah N
FAU - Basavaraju, Sridhar V
AU  - Basavaraju SV
FAU - Kuehnert, Matthew
AU  - Kuehnert M
FAU - Shaw, Tambi
AU  - Shaw T
LA  - eng
PT  - Journal Article
DEP - 20170804
PL  - United States
TA  - MMWR Morb Mortal Wkly Rep
JT  - MMWR. Morbidity and mortality weekly report
JID - 7802429
SB  - IM
MH  - Adult
MH  - California/epidemiology
MH  - *Disease Outbreaks
MH  - Genotype
MH  - Humans
MH  - Organ Transplantation/*adverse effects
MH  - Tuberculosis/*epidemiology/genetics/*transmission
PMC - PMC5720876
COIS- Conflict of Interest: No conflicts of interest were reported.
EDAT- 2017/08/05 06:00
MHDA- 2017/08/09 06:00
PMCR- 2017/08/04
CRDT- 2017/08/04 06:00
PHST- 2017/08/04 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2017/08/09 06:00 [medline]
PHST- 2017/08/04 00:00 [pmc-release]
AID - mm6630a1 [pii]
AID - 10.15585/mmwr.mm6630a1 [doi]
PST - epublish
SO  - MMWR Morb Mortal Wkly Rep. 2017 Aug 4;66(30):801-805. doi: 
      10.15585/mmwr.mm6630a1.