PMID- 28771563
OWN - NLM
STAT- MEDLINE
DCOM- 20171006
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 8
DP  - 2017
TI  - The effect of immunohistochemically detected p53 accumulation in prognosis of 
      breast cancer; A retrospective survey of outcome.
PG  - e0182444
LID - 10.1371/journal.pone.0182444 [doi]
LID - e0182444
AB  - BACKGROUND: P53; a tumor suppressor gene has known to have a role in a group of 
      human cancers. Its role in breast cancer; one of the most prevalent malignancies 
      worldwide, is still controversial. The current study is designed to evaluate the 
      prognostic role of p53 mutation in breast cancer. METHODS: one hundred and eighty 
      five breast cancer patients were studied in this retrospective study. P53 
      mutation was detected by accumulation of p53 protein in the patients' pathology 
      samples. Immunohistochemistry (IHC) was used to detect the protein. The effect of 
      p53 on the final outcome was assessed using Kaplan-Meier estimate of survival and 
      compared by log-rank test. Prognostic effects analyzed by cox proportional hazard 
      models. RESULTS: while the stage of the disease at presentation was not 
      significantly different between p53 positive and negative patients, those with 
      p53 mutation had a significantly poorer outcome in terms of overall and 
      disease-free survival rates (OS and DFS). In a multivariate analysis hazard ratio 
      of p53 mutation was about 5 and 3.8 for OS and DFS respectively. They also had a 
      higher cumulative incidence of relapse. CONCLUSION: It seems that p53 mutation is 
      an independent prognostic factor for breast cancer. Although larger prospective 
      studies are needed to clarify the importance of such a conclusion.
FAU - Sadighi, Sanambar
AU  - Sadighi S
AD  - Department of Medical Oncology, Cancer Research Center, Cancer Institute of Iran, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Zokaasadi, Mohammad
AU  - Zokaasadi M
AD  - Hematology, Oncology and Stem Cell Transplantation Research Center; Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Kasaeian, Amir
AU  - Kasaeian A
AD  - Hematology, Oncology and Stem Cell Transplantation Research Center; Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Maghsudi, Somaye
AU  - Maghsudi S
AD  - Hematology, Oncology and Stem Cell Transplantation Research Center; Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Jahanzad, Issa
AU  - Jahanzad I
AD  - Department of Pathology, Cancer Research Center, Cancer Institute of Iran, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Kamranzadeh Fumani, Hosein
AU  - Kamranzadeh Fumani H
AUID- ORCID: 0000-0002-6227-8994
AD  - Hematology, Oncology and Stem Cell Transplantation Research Center; Tehran 
      University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170803
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (TP53 protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Breast Neoplasms/genetics/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Middle Aged
MH  - Mutation/*genetics
MH  - Neoplasm Grading
MH  - Neoplasm Recurrence, Local/genetics/metabolism/*pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Survival Rate
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
PMC - PMC5542560
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/08/05 06:00
MHDA- 2017/10/07 06:00
PMCR- 2017/08/03
CRDT- 2017/08/04 06:00
PHST- 2017/05/07 00:00 [received]
PHST- 2017/07/18 00:00 [accepted]
PHST- 2017/08/04 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2017/10/07 06:00 [medline]
PHST- 2017/08/03 00:00 [pmc-release]
AID - PONE-D-17-17547 [pii]
AID - 10.1371/journal.pone.0182444 [doi]
PST - epublish
SO  - PLoS One. 2017 Aug 3;12(8):e0182444. doi: 10.1371/journal.pone.0182444. 
      eCollection 2017.