PMID- 28772224
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20170926
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1061-1062
DP  - 2017 Sep 1
TI  - Nanofibers mat-based solid-phase extraction method for the pretreatment of urine 
      samples and its application in the primary study on the disposition of 
      nonylphenol after long-term low-level exposure in rats.
PG  - 146-152
LID - S1570-0232(17)30570-6 [pii]
LID - 10.1016/j.jchromb.2017.07.004 [doi]
AB  - A method was established for the analysis of nonylphenol (NP) in rat urine 
      samples based on a solid-phase extraction (SPE) procedure with an amino 
      functionalized polyacrylonitrile nanofibers mat (NH(2)-PAN NF(S)M) as sorbent 
      coupled with high performance liquid chromatography-tandem mass spectrometry 
      (HPLC-MS/MS). The calibration curves prepared in three different days showed good 
      linearity over a wide range of NP concentrations from 0.1 to 100.0ng/mL. It was 
      remarkable that the proposed NH(2)-PAN NFsM based SPE method showed superior 
      extraction efficiency with the consumption of only 4mg of sorbent and 500muL of 
      eluent. The eluent without any further concentration was directly analyzed by 
      HPLC-MS/MS. As a result, a simple and effective sample preparation was achieved. 
      In addition, the notable lower detection limit (LOD) of 0.03ng/mL revealed the 
      excellent sensitivity of the proposed method in comparison with that in 
      literatures. The recoveries ranged from 85.0% to 114.8% with the relative 
      standard deviations (RSDs) ranging from 7.5% to 13.7%, which were better than or 
      comparable to those from the published methods, suggesting high accuracy of the 
      proposed method. The proposed method was applied in primary study on the 
      disposition of nonylphenol after long-term low-level exposure in rats, providing 
      information for health risk assessment on the real scenarios of NP exposure. 
      NH(2)-PAN NFsM shows great potential as a novel SPE sorbent for the analysis of 
      biological samples.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Qian, Liangliang
AU  - Qian L
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, China.
FAU - Li, Ruixian
AU  - Li R
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, China.
FAU - Di, Qiannan
AU  - Di Q
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, China.
FAU - Shen, Yang
AU  - Shen Y
AD  - Department of Obstetrics and Gynecology, Zhong Da Hospital, School of Medicine, 
      Southeast University, Nanjing 210009, China.
FAU - Xu, Qian
AU  - Xu Q
AD  - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, China; Suzhou Key 
      Laboratory of Environment and Biosafety, Suzhou 215123, China. Electronic 
      address: q_xu68@163.com.
FAU - Li, Jian
AU  - Li J
AD  - Su Zhou Municipal Center For Disease Prevention and Control, Suzhou 215004, 
      China. Electronic address: 1055729273@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20170731
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 0 (Phenols)
RN  - 79F6A2ILP5 (nonylphenol)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Female
MH  - Limit of Detection
MH  - Linear Models
MH  - Nanofibers/*chemistry
MH  - Phenols/*urine
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproducibility of Results
MH  - Solid Phase Extraction/*methods
MH  - Tandem Mass Spectrometry
MH  - Toxicity Tests, Chronic
OTO - NOTNLM
OT  - Amino functionalized nanofibers mat
OT  - Biomonitoring
OT  - Long-term low level nonylphenol exposure
OT  - Rat urine samples
OT  - Solid-phase extraction
EDAT- 2017/08/05 06:00
MHDA- 2017/09/28 06:00
CRDT- 2017/08/04 06:00
PHST- 2017/04/02 00:00 [received]
PHST- 2017/06/02 00:00 [revised]
PHST- 2017/07/02 00:00 [accepted]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2017/08/04 06:00 [entrez]
AID - S1570-0232(17)30570-6 [pii]
AID - 10.1016/j.jchromb.2017.07.004 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:146-152. doi: 
      10.1016/j.jchromb.2017.07.004. Epub 2017 Jul 31.