PMID- 28774662 OWN - NLM STAT- MEDLINE DCOM- 20180510 LR - 20181202 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 258 DP - 2017 Dec TI - Hamilton rating scale for depression-24 (HAM-D(24)) as a novel predictor for diabetic microvascular complications in type 2 diabetes mellitus patients. PG - 177-183 LID - S0165-1781(17)30089-6 [pii] LID - 10.1016/j.psychres.2017.07.050 [doi] AB - The study was designed to investigate whether the hamilton rating scale for depression (24-items) (HAM-D(24)) can be used to predict the diabetic microvascular complications in type 2 diabetes mellitus (T2DM) patients. 288 hospitalized patients with T2DM were enrolled. Their diabetic microvascular complications including diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy and diabetic foot as well as demographic, clinical data, blood samples and echocardiography were documented. All the enrolled patients received HAM-D(24) evaluation. The HAM-D(24) score and incidence of depression in T2DM patients with each diabetic microvascular complication were significantly higher than those in T2DM patients without each diabetic microvascular complication. After the adjustment of use of insulin and hypoglycemic drug, duration of T2DM, mean platelet volume, creatinine, albumin, fasting glucose, glycosylated hemoglobin type A1C, left ventricular ejection fraction, respectively, HAM-D(24) score was still significantly associated with diabetic microvascular complications (OR = 1.188-1.281, all P < 0.001). The AUC of HAM-D(24) score for the prediction of diabetic microvascular complication was 0.832 (0.761-0.902). 15 points of HAM-D(24) score was considered as the optimal cutoff with the sensitivity of 0.778 and specificity of 0.785. In summary, HAM-D(24) score may be used as a novel predictor of diabetic microvascular complications in T2DM patients. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Pan, Shuo AU - Pan S AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Liu, Zhong-Wei AU - Liu ZW AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Shi, Shuang AU - Shi S AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Ma, Xun AU - Ma X AD - Department of Emergency Medicine, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Song, Wen-Qian AU - Song WQ AD - Department of Internal Medicine, University Hospital of Northwest University, Xi'an, Shaanxi, People's Republic of China. FAU - Guan, Gong-Chang AU - Guan GC AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Zhang, Yong AU - Zhang Y AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Zhu, Shun-Ming AU - Zhu SM AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Liu, Fu-Qiang AU - Liu FQ AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Liu, Bo AU - Liu B AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Tang, Zhi-Guo AU - Tang ZG AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. FAU - Wang, Jun-Kui AU - Wang JK AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. Electronic address: wjk_sx@163.com. FAU - Lv, Ying AU - Lv Y AD - First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, Shaanxi, People's Republic of China. Electronic address: springlvy@163.com. LA - eng PT - Journal Article DEP - 20170726 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Area Under Curve MH - Depression/*complications MH - Diabetes Mellitus, Type 2/*complications MH - Diabetic Angiopathies/*complications/*diagnosis MH - Diabetic Foot/complications/diagnosis MH - Diabetic Nephropathies/complications/diagnosis MH - Diabetic Neuropathies/complications/diagnosis MH - Diabetic Retinopathy/complications/diagnosis MH - Female MH - Humans MH - Male MH - Middle Aged MH - Sensitivity and Specificity OTO - NOTNLM OT - Diabetic complications OT - Hamilton rating scale for depression OT - Microvascular OT - Type 2 diabetes mellitus EDAT- 2017/08/05 06:00 MHDA- 2018/05/11 06:00 CRDT- 2017/08/05 06:00 PHST- 2017/01/15 00:00 [received] PHST- 2017/07/25 00:00 [accepted] PHST- 2017/08/05 06:00 [pubmed] PHST- 2018/05/11 06:00 [medline] PHST- 2017/08/05 06:00 [entrez] AID - S0165-1781(17)30089-6 [pii] AID - 10.1016/j.psychres.2017.07.050 [doi] PST - ppublish SO - Psychiatry Res. 2017 Dec;258:177-183. doi: 10.1016/j.psychres.2017.07.050. Epub 2017 Jul 26.