PMID- 28774935 OWN - NLM STAT- MEDLINE DCOM- 20181015 LR - 20181015 IS - 1468-2079 (Electronic) IS - 0007-1161 (Linking) VI - 102 IP - 3 DP - 2018 Mar TI - Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis. PG - 344-351 LID - 10.1136/bjophthalmol-2016-310111 [doi] AB - AIM: To compare the cube and radial scan patterns of the spectral domain optical coherence tomography (SD-OCT) for quantifying the Bruch's membrane opening minimum rim width (BMO-MRW). METHODS: Sixty healthy eyes and 189 glaucomatous eyes were included. The optic nerve head cube and radial pattern scans were acquired using Spectralis SD-OCT. BMO-MRWs were automatically delineated using the San Diego Automated Layer Segmentation Algorithm. The BMO-MRW diagnostic accuracy for glaucoma detection and rates of change derived from the two scan patterns were compared. RESULTS: There was a significant difference between the baseline global BMO-MRW measurements of cube and radial scans for healthy (301.9+/-57.8 microm and 334.7+/-61.8 microm, respectively, p<0.003) and glaucoma eyes (181.2+/-63.0 microm and 210.2+/-67.2 microm, respectively, p<0.001). The area under the receiver operating characteristic curve for differentiating between healthy and glaucoma eyes was 0.90 for both the radial scan-based and cube scan-based BMO-MRW. No significant difference in the rate of BMO-MRW change (mean follow-up years) by scan pattern was found among both healthy (cube: -1.47 microm/year, radial: -1.53 microm/year; p=0.48) (1.6 years) and glaucoma eyes (cube: -2.37 microm/year, radial: -2.28 microm/year; p=0.45) (2.6 years). CONCLUSION: Although the cube scan-based BMO-MRW was significantly smaller than the radial scan-based BMO-MRW, we found no significant difference between the two scan patterns for detecting glaucoma, identifying BMO location and measuring the rate of BMO-MRW change. These results suggest that although BMO-MRW estimates are not interchangeable, both scan patterns can be used for monitoring BMO-MRW changes over time. CI - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. FAU - Kabbara, Sami W AU - Kabbara SW AD - Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, California, USA. FAU - Zangwill, Linda M AU - Zangwill LM AD - Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, California, USA. FAU - Mundae, Rusdeep AU - Mundae R AD - Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, California, USA. FAU - Hammel, Naama AU - Hammel N AD - Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, California, USA. FAU - Bowd, Christopher AU - Bowd C AD - Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, California, USA. FAU - Medeiros, Felipe A AU - Medeiros FA AD - Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, California, USA. FAU - Weinreb, Robert N AU - Weinreb RN AD - Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, California, USA. FAU - Belghith, Akram AU - Belghith A AD - Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, California, USA. LA - eng GR - P30 EY022589/EY/NEI NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20170803 PL - England TA - Br J Ophthalmol JT - The British journal of ophthalmology JID - 0421041 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Bruch Membrane/*diagnostic imaging MH - Cross-Sectional Studies MH - Female MH - Follow-Up Studies MH - Glaucoma, Open-Angle/*diagnostic imaging MH - Healthy Volunteers MH - Humans MH - Intraocular Pressure MH - Male MH - Middle Aged MH - Nerve Fibers/*pathology MH - Ocular Hypertension/diagnostic imaging MH - Optic Disk/*diagnostic imaging MH - ROC Curve MH - Reproducibility of Results MH - Retinal Ganglion Cells/*pathology MH - Tomography, Optical Coherence/*methods MH - Visual Fields MH - Young Adult OTO - NOTNLM OT - BMO OT - BMO-MRW OT - Glaucoma OT - OCT COIS- Competing interests: FAM: Carl-Zeiss Meditec, Dublin, CA; Heidelberg Engineering, Heidelberg, Germany; Topcon Medical Systems, Tokyo, Japan; Ametek, Berwyn, PA; Bausch+Lomb, Bridgewater, NJ; Allergan, Dublin, Ireland; Sensimed AG, Lausanne, Switzerland; Alcon Laboratories, Fort Worth, TX. RNW: Alcon Laboratories, Fort Worth, TX; Allergan, Dublin, Ireland; Bausch+Lomb, Bridgewater, NJ; Carl-Zeiss Meditec, Dublin, CA; Topcon Medical Systems, Tokyo, Japan; Heidelberg Engineering, Heidelberg, Germany; Genentech, San Francisco, CA; Optovue, Fremont, CA. LMZ: Carl Zeiss Meditec, Dublin, CA; Heidelberg Engineering, Heidelberg, Germany; Optovue, Fremont, CA; Topcon Medical Systems, Tokyo, Japan; Quark Pharmaceuticals, Fremont, CA. EDAT- 2017/08/05 06:00 MHDA- 2018/10/16 06:00 CRDT- 2017/08/05 06:00 PHST- 2016/12/23 00:00 [received] PHST- 2017/05/09 00:00 [revised] PHST- 2017/06/12 00:00 [accepted] PHST- 2017/08/05 06:00 [pubmed] PHST- 2018/10/16 06:00 [medline] PHST- 2017/08/05 06:00 [entrez] AID - bjophthalmol-2016-310111 [pii] AID - 10.1136/bjophthalmol-2016-310111 [doi] PST - ppublish SO - Br J Ophthalmol. 2018 Mar;102(3):344-351. doi: 10.1136/bjophthalmol-2016-310111. Epub 2017 Aug 3.