PMID- 28776088
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20181202
IS  - 1619-7089 (Electronic)
IS  - 1619-7070 (Print)
IS  - 1619-7070 (Linking)
VI  - 44
IP  - 12
DP  - 2017 Nov
TI  - Impact of partial-volume correction in oncological PET studies: a systematic 
      review and meta-analysis.
PG  - 2105-2116
LID - 10.1007/s00259-017-3775-4 [doi]
AB  - PURPOSE: Positron-emission tomography can be useful in oncology for diagnosis, 
      (re)staging, determining prognosis, and response assessment. However, 
      partial-volume effects hamper accurate quantification of lesions <2-3x the PET 
      system's spatial resolution, and the clinical impact of this is not evident. This 
      systematic review provides an up-to-date overview of studies investigating the 
      impact of partial-volume correction (PVC) in oncological PET studies. METHODS: We 
      searched in PubMed and Embase databases according to the PRISMA statement, 
      including studies from inception till May 9, 2016. Two reviewers independently 
      screened all abstracts and eligible full-text articles and performed quality 
      assessment according to QUADAS-2 and QUIPS criteria. For a set of similar 
      diagnostic studies, we statistically pooled the results using bivariate 
      meta-regression. RESULTS: Thirty-one studies were eligible for inclusion. 
      Overall, study quality was good. For diagnosis and nodal staging, PVC yielded a 
      strong trend of increased sensitivity at expense of specificity. Meta-analysis of 
      six studies investigating diagnosis of pulmonary nodules (679 lesions) showed no 
      significant change in diagnostic accuracy after PVC (p = 0.222). Prognostication 
      was not improved for non-small cell lung cancer and esophageal cancer, whereas it 
      did improve for head and neck cancer. Response assessment was not improved by PVC 
      for (locally advanced) breast cancer or rectal cancer, and it worsened in 
      metastatic colorectal cancer. CONCLUSIONS: The accumulated evidence to date does 
      not support routine application of PVC in standard clinical PET practice. 
      Consensus on the preferred PVC methodology in oncological PET should be reached. 
      Partial-volume-corrected data should be used as adjuncts to, but not yet 
      replacement for, uncorrected data.
FAU - Cysouw, Matthijs C F
AU  - Cysouw MCF
AD  - Department of Radiology and Nuclear Medicine, VU University Medical Centre, P.O. 
      Box 7057, 1007 MB, Amsterdam, Netherlands.
FAU - Kramer, Gerbrand M
AU  - Kramer GM
AD  - Department of Radiology and Nuclear Medicine, VU University Medical Centre, P.O. 
      Box 7057, 1007 MB, Amsterdam, Netherlands.
FAU - Schoonmade, Linda J
AU  - Schoonmade LJ
AD  - Department of Medical Library, VU University Medical Centre, Amsterdam, 
      Netherlands.
FAU - Boellaard, Ronald
AU  - Boellaard R
AD  - Department of Radiology and Nuclear Medicine, VU University Medical Centre, P.O. 
      Box 7057, 1007 MB, Amsterdam, Netherlands.
AD  - Department of Nuclear Medicine & Molecular Imaging, University Medical Centre 
      Groningen, Groningen, Netherlands.
FAU - de Vet, Henrica C W
AU  - de Vet HCW
AD  - Department of Epidemiology and Biostatistics, VU University Medical Centre, 
      Amsterdam, Netherlands.
FAU - Hoekstra, Otto S
AU  - Hoekstra OS
AD  - Department of Radiology and Nuclear Medicine, VU University Medical Centre, P.O. 
      Box 7057, 1007 MB, Amsterdam, Netherlands. os.hoekstra@vumc.nl.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20170804
PL  - Germany
TA  - Eur J Nucl Med Mol Imaging
JT  - European journal of nuclear medicine and molecular imaging
JID - 101140988
SB  - IM
MH  - Humans
MH  - Neoplasm Staging
MH  - Neoplasms/*diagnostic imaging/pathology
MH  - Positron-Emission Tomography/*methods
PMC - PMC5656693
OTO - NOTNLM
OT  - Oncology
OT  - Partial-volume correction
OT  - Partial-volume effect
OT  - Pet
OT  - Quantification
COIS- FUNDING: This study required no funding. CONFLICT OF INTEREST: The authors 
      declare that they have no conflict of interest. ETHICAL APPROVAL: This article 
      does not contain any studies with human participants performed by any of the 
      authors. INFORMED CONSENT: For a systematic review, acquiring informed consent is 
      not applicable.
EDAT- 2017/08/05 06:00
MHDA- 2018/05/31 06:00
PMCR- 2017/08/04
CRDT- 2017/08/05 06:00
PHST- 2017/05/08 00:00 [received]
PHST- 2017/07/02 00:00 [accepted]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
PHST- 2017/08/05 06:00 [entrez]
PHST- 2017/08/04 00:00 [pmc-release]
AID - 10.1007/s00259-017-3775-4 [pii]
AID - 3775 [pii]
AID - 10.1007/s00259-017-3775-4 [doi]
PST - ppublish
SO  - Eur J Nucl Med Mol Imaging. 2017 Nov;44(12):2105-2116. doi: 
      10.1007/s00259-017-3775-4. Epub 2017 Aug 4.