PMID- 28777838
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20190930
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Linking)
VI  - 22
IP  - 8
DP  - 2017 Aug 1
TI  - Quantitative attenuation analysis for identification of early Barrett's neoplasia 
      in volumetric laser endomicroscopy.
PG  - 86001
LID - 10.1117/1.JBO.22.8.086001 [doi]
AB  - Early neoplasia in Barrett's esophagus (BE) is difficult to detect. Volumetric 
      laser endomicroscopy (VLE) incorporates optical coherence tomography, providing a 
      circumferential scan of the esophageal wall layers. The attenuation coefficient 
      (muVLE) quantifies decay of detected backscattered light versus depth, and could 
      potentially improve BE neoplasia detection. The aim is to investigate feasibility 
      of muVLE for identification of early BE neoplasia. In vivo and ex vivo VLE scans 
      with histological correlation from BE patients +/- neoplasia were used. 
      Quantification by muVLE was performed manually on areas of interest (AoIs) to 
      differentiate neoplasia from nondysplastic (ND)BE. From ex vivo VLE scans from 16 
      patients (13 with neoplasia), 68 AoIs were analyzed. Median muVLE values (mm-1) 
      were 3.7 [2.1 to 4.4 interquartile range (IQR)] for NDBE and 4.0 (2.5 to 4.9 IQR) 
      for neoplasia, not statistically different (p=0.82). Fourteen in vivo scans were 
      used: nine from neoplastic and five from NDBE patients. Median muVLE values were 
      1.8 (1.5 to 2.6 IQR) for NDBE and 2.1 (1.9 to 2.6 IQR) for neoplasia, with no 
      statistically significant difference (p=0.37). In conclusion, there was no 
      significant difference in muVLE values in VLE scans from early neoplasia versus 
      NDBE. Future studies with a larger sample size should explore other quantitative 
      methods for detection of neoplasia during BE surveillance.
FAU - Swager, Anne-Fre
AU  - Swager AF
AD  - , Department of Gastroenterology and Hepatology, Academic Medical Center, 
      Amsterdam.
FAU - Faber, Dirk J
AU  - Faber DJ
AD  - , Department of Biomedical Engineering and Physics, Academic Medical Center, 
      Amsterdam.
FAU - de Bruin, Daniel M
AU  - de Bruin DM
AD  - , Department of Biomedical Engineering and Physics, Academic Medical Center, 
      Amsterdam.
FAU - Weusten, Bas L
AU  - Weusten BL
AD  - , Department of Gastroenterology and Hepatology, Academic Medical Center, 
      Amsterdam.
FAU - Meijer, Sybren L
AU  - Meijer SL
AD  - , Department of Pathology, Academic Medical Center, Amsterdam.
FAU - Bergman, Jacques J
AU  - Bergman JJ
AD  - , Department of Gastroenterology and Hepatology, Academic Medical Center, 
      Amsterdam.
FAU - Curvers, Wouter L
AU  - Curvers WL
AD  - , Department of Gastroenterology and Hepatology, Eindhoven.
FAU - van Leeuwen, Ton G
AU  - van Leeuwen TG
AD  - , Department of Biomedical Engineering and Physics, Academic Medical Center, 
      Amsterdam.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
SB  - IM
MH  - Algorithms
MH  - Barrett Esophagus/*diagnostic imaging/pathology/surgery
MH  - Endoscopy, Gastrointestinal
MH  - Esophagus/*diagnostic imaging/pathology/surgery
MH  - Histocytochemistry
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Microscopy, Confocal/*methods
MH  - Signal Processing, Computer-Assisted
EDAT- 2017/08/05 06:00
MHDA- 2018/06/23 06:00
CRDT- 2017/08/05 06:00
PHST- 2017/02/13 00:00 [received]
PHST- 2017/07/17 00:00 [accepted]
PHST- 2017/08/05 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
AID - 2648213 [pii]
AID - 10.1117/1.JBO.22.8.086001 [doi]
PST - ppublish
SO  - J Biomed Opt. 2017 Aug 1;22(8):86001. doi: 10.1117/1.JBO.22.8.086001.