PMID- 28777856
OWN - NLM
STAT- MEDLINE
DCOM- 20171205
LR  - 20171205
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 34
IP  - 4
DP  - 2017 Aug 10
TI  - [Clinical and laboratory features of 13 cases of myeloid neoplasms with double 
      del (20q)].
PG  - 546-549
LID - 10.3760/cma.j.issn.1003-9406.2017.04.017 [doi]
AB  - OBJECTIVE: To report on clinical and laboratory features of myeloid neoplasms 
      with double del(20q). METHODS: Cytogenetic examination of bone marrow was 
      performed on 13 cases of myeloid neophasms with double del(20q) after 24 hours of 
      cell culture. R-banding was used to analyze the karyotypes. Interphase 
      fluorescence in situ hybridization (FISH) was performed using dual-color probes 
      for 20q11/20q12. RESULTS: Double del(20q) was found to be the sole abnormality in 
      9 cases, double del(20q) and trisomy 9 was found in 1 case, trisomy del(20q) was 
      found in 1 case, and sole del(20q) clone and double del(20q) clone were found to 
      coexist in 2 cases. In 10 cases, interphase FISH showed one green and one red 
      signal in cells with del(20q), which indicated deletion of both 20q11 and 20q12. 
      Immunophenotyping of the leukemia cells showed positiveness for CD13 and/or CD33, 
      CD117 in all 9 cases. Among these, co-expression of CD34 and/or HLA-DR was found 
      in 6 cases, and coexpression of CD3 and CD7 was found in 1 case. Of the 13 cases, 
      there were one AML-M6, nine MDS, one pure amegalokaryocye aplastic 
      thrombocytopenia, one with normal morphology of bone marrow, and one undetermined 
      due to dilution of the bone marrow by blood. Cytopenia were found in all cases. 9 
      of 13 cases died, and 4 survived with a median survival of 9 months. CONCLUSION: 
      Double del(20q) is a rare but recurrent chromosomal abnormality derived from 
      del(20q). It has unique clinical and laboratory features, and the prognosis is 
      poor.
FAU - Bai, Shuxiao
AU  - Bai S
AD  - Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of 
      the Ministry of Health, The First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu 215006, China. Jinlanpan@aliyun.com.
FAU - Wu, Chunxiao
AU  - Wu C
FAU - Zhang, Jun
AU  - Zhang J
FAU - Chen, Suning
AU  - Chen S
FAU - Pan, Jinlan
AU  - Pan J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Aged
MH  - Chromosome Banding/methods
MH  - Chromosome Deletion
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
MH  - Neoplasms/*genetics
EDAT- 2017/08/05 06:00
MHDA- 2017/12/06 06:00
CRDT- 2017/08/05 06:00
PHST- 2017/08/05 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2017/12/06 06:00 [medline]
AID - 940634111 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2017.04.017 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Aug 10;34(4):546-549. doi: 
      10.3760/cma.j.issn.1003-9406.2017.04.017.