PMID- 28777866
OWN - NLM
STAT- MEDLINE
DCOM- 20171205
LR  - 20180816
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 34
IP  - 4
DP  - 2017 Aug 10
TI  - [Association of Val66Met polymorphism of brain-derived neurotrophic factor gene 
      with cognitive impairment and clinical symptoms in first episode schizophrenia].
PG  - 592-596
LID - 10.3760/cma.j.issn.1003-9406.2017.04.027 [doi]
AB  - OBJECTIVE: To assess the association of cognitive impairment and clinical 
      symptoms in first-episode schizophrenia with the Val66Met (rs6265) polymorphism 
      of brain-derived neurotrophic factor (BDNF) gene. METHODS: For 87 patients with 
      first-episode schizophrenia and 76 healthy controls, the Val66Met polymorphism 
      was determined with a Taqman Assay-on-Demand method. Wechsler intelligence test 
      was carried out for all participants. Correlation of cognitive impairment with 
      clinical severity was also analyzed. RESULTS: The patients were significantly 
      lower in total IQ, verbal IQ and performance IQ compared to the controls. The 
      lower total IQ (F=4.59, P= 0.01) and verbal IQ (F=4.44, P=0.01) were influenced 
      by genetic factors and diagnostic interaction. The vertal IQ of Val/Val patients 
      was significantly lower than those of Val/Met and Met/Met carriers. For the 
      control group, the verbal IQ of Met/Met carriers was lower than that of Val/Met 
      carriers, and the total IQ of Met/Met carriers was lower than those of Val/Met 
      and Val/Val carriers. For the patient group, the total IQ of Val/Val carriers was 
      negatively correlated with positive symptoms (r=-0.65, P=0.03) and thought 
      disorders (r=-0.61, P=0.02). CONCLUSION: Cognitive impairment in first-episode 
      schizophrenic patients is associated with the Val66Met polymorphism of the BDNF 
      gene, and has an important clinical relevance.
FAU - Zhang, Chengcheng
AU  - Zhang C
AD  - Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, 
      Sichuan 610041, China. xuntao26@hotmail.com.
FAU - Gu, Xiaochu
AU  - Gu X
FAU - Wang, Qiang
AU  - Wang Q
FAU - Li, Mingli
AU  - Li M
FAU - Deng, Wei
AU  - Deng W
FAU - Guo, Wanjun
AU  - Guo W
FAU - Zhao, Liansheng
AU  - Zhao L
FAU - Ma, Xiaohong
AU  - Ma X
FAU - Li, Tao
AU  - Li T
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Cognitive Dysfunction/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Schizophrenia/*genetics
MH  - Young Adult
EDAT- 2017/08/05 06:00
MHDA- 2017/12/06 06:00
CRDT- 2017/08/05 06:00
PHST- 2017/08/05 06:00 [entrez]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2017/12/06 06:00 [medline]
AID - 940634121 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2017.04.027 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Aug 10;34(4):592-596. doi: 
      10.3760/cma.j.issn.1003-9406.2017.04.027.