PMID- 28777966
OWN - NLM
STAT- MEDLINE
DCOM- 20180413
LR  - 20221207
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 179
DP  - 2017 Oct 1
TI  - Long-term heroin use was associated with the downregulation of systemic 
      platelets, BDNF, and TGF-beta1, and it contributed to the disruption of executive 
      function in Taiwanese Han Chinese.
PG  - 139-145
LID - S0376-8716(17)30370-8 [pii]
LID - 10.1016/j.drugalcdep.2017.06.035 [doi]
AB  - BACKGROUND: Long-term heroin addicts have low plasma brain-derived neurotrophic 
      factor (BDNF) levels. However, the mechanisms and effects of systemic 
      disturbances of BDNF caused by heroin remain unclear. OBJECTIVE: Blood platelet 
      might be a source of neurotrophic factors like BDNF and transforming growth 
      factor (TGF)-beta1. Thus, we investigated the effects of heroin on platelets, BDNF 
      and TGF-beta1, the association between blood platelets, BDNF, TGF-beta1, and executive 
      function in long-term heroin addicts. METHODS: We enrolled 170 heroin addicts and 
      141 healthy controls. We measured their plasma BDNF and TGF-beta1 levels and counted 
      their platelets, red and white blood cells. The Wisconsin Card Sorting Test 
      (WCST) was used to assess their executive function. RESULTS: Plasma BDNF and 
      TGF-beta1 levels were significantly downregulated in long-term heroin addicts. BDNF, 
      TGF-beta1, and platelet levels were lower in patients who had used heroin for more 
      than 6 years than in those who had used it for less than 6 years. Lower plasma 
      BDNF and TGF-beta1 levels were highly correlated with the changes in platelet 
      counts. In the WCST, the number of trials needed to complete the first category 
      were negatively associated with platelet counts and BDNF levels. CONCLUSIONS: In 
      long-term heroin addicts, lower platelet counts contributed to lower plasma BDNF 
      and TGF-beta1 levels, which, in turn, contributed to the disruption of executive 
      function after long-term heroin use. Neurotrophic- and platelet-protective agents 
      might provide a useful research focus for heroin addiction therapy.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Lu, Ru-Band
AU  - Lu RB
AD  - Department of Psychiatry, National Cheng Kung University (NCKU) Hospital, Tainan, 
      Taiwan; Department of Psychiatry, NCKU, Tainan, Taiwan; Institute of Behavioral 
      Medicine, NCKU, Tainan, Taiwan; Institute of Allied Health Sciences, College of 
      Medicine, NCKU, Tainan, Taiwan; Addiction Research Center, NCKU, Tainan, Taiwan; 
      Center for Neuropsychiatric Research, National Health Research Institutes, 
      Miaoli, Taiwan.
FAU - Lee, Sheng-Yu
AU  - Lee SY
AD  - Department of Psychiatry, National Cheng Kung University (NCKU) Hospital, Tainan, 
      Taiwan; Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, 
      Taiwan.
FAU - Wang, Tzu-Yun
AU  - Wang TY
AD  - Department of Psychiatry, National Cheng Kung University (NCKU) Hospital, Tainan, 
      Taiwan; Department of Psychiatry, NCKU, Tainan, Taiwan.
FAU - Chang, Yun-Hsuan
AU  - Chang YH
AD  - Department of Psychiatry, NCKU, Tainan, Taiwan; Institute of Allied Health 
      Sciences, College of Medicine, NCKU, Tainan, Taiwan; Department of Psychology, 
      Asia University, Taichung, Taiwan.
FAU - Chen, Po-See
AU  - Chen PS
AD  - Department of Psychiatry, National Cheng Kung University (NCKU) Hospital, Tainan, 
      Taiwan; Department of Psychiatry, NCKU, Tainan, Taiwan; Addiction Research 
      Center, NCKU, Tainan, Taiwan.
FAU - Yang, Yen-Kuang
AU  - Yang YK
AD  - Department of Psychiatry, National Cheng Kung University (NCKU) Hospital, Tainan, 
      Taiwan; Department of Psychiatry, NCKU, Tainan, Taiwan; Institute of Behavioral 
      Medicine, NCKU, Tainan, Taiwan; Addiction Research Center, NCKU, Tainan, Taiwan.
FAU - Hong, Jau-Shyong
AU  - Hong JS
AD  - Neurobiology Laboratory, NIH/NIEHS, Research Triangle Park, NC, USA.
FAU - Chen, Shiou-Lan
AU  - Chen SL
AD  - Graduate Institute of Medicine and M.Sc. Program in Tropical Medicine, College of 
      Medicine, Kaohsiung Medical University (KMU), Kaohsiung, Taiwan; Department of 
      Medical Research, KMU Hospital, Kaohsiung, Taiwan; Department of Psychiatry, 
      National Cheng Kung University (NCKU) Hospital, Tainan, Taiwan. Electronic 
      address: shioulan@kmu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20170727
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Asian People
MH  - Blood Platelets
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Down-Regulation
MH  - Executive Function
MH  - Heroin Dependence/blood/*metabolism
MH  - Humans
MH  - Leukocytes/chemistry/*metabolism
MH  - Transforming Growth Factor beta1
OTO - NOTNLM
OT  - BDNF
OT  - Heroin
OT  - Platelets
OT  - TGF-beta1
EDAT- 2017/08/05 06:00
MHDA- 2018/04/14 06:00
CRDT- 2017/08/05 06:00
PHST- 2017/01/18 00:00 [received]
PHST- 2017/06/23 00:00 [revised]
PHST- 2017/06/26 00:00 [accepted]
PHST- 2017/08/05 06:00 [pubmed]
PHST- 2018/04/14 06:00 [medline]
PHST- 2017/08/05 06:00 [entrez]
AID - S0376-8716(17)30370-8 [pii]
AID - 10.1016/j.drugalcdep.2017.06.035 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2017 Oct 1;179:139-145. doi: 
      10.1016/j.drugalcdep.2017.06.035. Epub 2017 Jul 27.