PMID- 2877842
OWN - NLM
STAT- MEDLINE
DCOM- 19870120
LR  - 20190903
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 18
IP  - 2
DP  - 1986 Oct
TI  - Self-administration of methylenedioxymethamphetamine (MDMA) by rhesus monkeys.
PG  - 149-57
AB  - Four rhesus monkeys trained to press levers for intravenous cocaine infusions 
      were tested with saline and (+/-)-3,4-methylenedioxymethamphetamine (MDMA; 3-300 
      micrograms/kg per infusion) during daily 1-h sessions. From four to over nine 
      times more cocaine infusions were obtained than saline infusions during baseline 
      sessions. When MDMA was substituted for cocaine, at least one dose was 
      self-administered in 3 of the 4 monkeys at rates that exceeded the range of 
      saline infusions. In fact, two of the monkeys self-administered a dose of MDMA at 
      a greater rate than cocaine. These results demonstrate that MDMA can serve as a 
      positive reinforcer for rhesus monkeys and, taken together with other preclinical 
      behavioral studies, suggest a potential for recreational use of MDMA by humans.
FAU - Beardsley, P M
AU  - Beardsley PM
FAU - Balster, R L
AU  - Balster RL
FAU - Harris, L S
AU  - Harris LS
LA  - eng
GR  - 271-81-3830/PHS HHS/United States
GR  - DA-07027/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Cocaine/pharmacology
MH  - Macaca mulatta
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Self Administration
EDAT- 1986/10/01 00:00
MHDA- 1986/10/01 00:01
CRDT- 1986/10/01 00:00
PHST- 1986/10/01 00:00 [pubmed]
PHST- 1986/10/01 00:01 [medline]
PHST- 1986/10/01 00:00 [entrez]
AID - 0376-8716(86)90047-5 [pii]
AID - 10.1016/0376-8716(86)90047-5 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 1986 Oct;18(2):149-57. doi: 10.1016/0376-8716(86)90047-5.