PMID- 28778479
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 262
DP  - 2017 Sep 28
TI  - Mesoporous silica materials: From physico-chemical properties to enhanced 
      dissolution of poorly water-soluble drugs.
PG  - 329-347
LID - S0168-3659(17)30767-8 [pii]
LID - 10.1016/j.jconrel.2017.07.047 [doi]
AB  - New approaches in pharmaceutical chemistry have resulted in more complex drug 
      molecules in the quest to achieve higher affinity to their targets. However, 
      these 'highly active' drugs can also suffer from poor water solubility. Hence, 
      poorly water soluble drugs became a major challenge in drug formulation, and this 
      problem is increasing, as currently about 40 of the marketed drugs and 90% of 
      drug candidates are classified as poorly water soluble. Various approaches exist 
      to circumvent poor water solubility and poor dissolution rate in aqueous 
      environment, however, each having disadvantages and certain limitations. 
      Recently, mesoporous silica materials (MSMs) have been proposed to be used as 
      matrices for enhancing the apparent solubility and dissolution rate of different 
      drug molecules. MSMs are ideal candidates for this purpose, as silica is a 
      "generally regarded as safe" (GRAS) material, is biodegradable, and can be 
      readily surface-modified in order to optimize drug loading and subsequent release 
      in the human body. The major advantage of mesoporous silica as drug delivery 
      systems (DDSs) for poorly water soluble drugs lies in their pore size, pore 
      morphology, and versatility in alteration of the surface groups, which can result 
      in optimized interactions between a drug candidate and MSM carrier by modifying 
      the pore surfaces. Furthermore, the drug of interest can be loaded into these 
      pores in a preferably amorphous state, which can increase the drug dissolution 
      properties dramatically. The highlights of this review include a critical 
      discussion about the modification of the physico-chemical properties of MSMs and 
      how these physico-chemical modifications influence the drug loading and the 
      subsequent dissolution of poorly water soluble drugs. It aims to further promote 
      the use of MSMs as alternative strategy to common methods like solubility 
      enhancement by cyclodextrins, micronization, or microemulsion techniques. This 
      review can provide guidance on how to tailor MSMs to achieve optimized drug 
      loading and drug dissolution.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Maleki, Aziz
AU  - Maleki A
AD  - Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University 
      of Medical Sciences, Zanjan, Iran.
FAU - Kettiger, Helene
AU  - Kettiger H
AD  - Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Abo 
      Akademi University, Tykistokatu 6A, FI-20520 Turku, Finland.
FAU - Schoubben, Aurelie
AU  - Schoubben A
AD  - Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, 
      Italy.
FAU - Rosenholm, Jessica M
AU  - Rosenholm JM
AD  - Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Abo 
      Akademi University, Tykistokatu 6A, FI-20520 Turku, Finland. Electronic address: 
      jerosenh@abo.fi.
FAU - Ambrogi, Valeria
AU  - Ambrogi V
AD  - Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, 
      Italy. Electronic address: valeria.ambrogi@unipg.it.
FAU - Hamidi, Mehrdad
AU  - Hamidi M
AD  - Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University 
      of Medical Sciences, Zanjan, Iran. Electronic address: hamidim@zums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170802
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Pharmaceutical Preparations)
RN  - 059QF0KO0R (Water)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Animals
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Humans
MH  - Pharmaceutical Preparations/administration & dosage/chemistry
MH  - Porosity
MH  - Silicon Dioxide/administration & dosage/*chemistry
MH  - Solubility
MH  - Water/chemistry
OTO - NOTNLM
OT  - Dissolution enhancement
OT  - Mesoporous silica materials
OT  - Oral bioavailability
OT  - Physico-chemical properties
OT  - Poorly water-soluble drugs
EDAT- 2017/08/06 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/08/06 06:00
PHST- 2017/06/13 00:00 [received]
PHST- 2017/06/24 00:00 [revised]
PHST- 2017/07/31 00:00 [accepted]
PHST- 2017/08/06 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/08/06 06:00 [entrez]
AID - S0168-3659(17)30767-8 [pii]
AID - 10.1016/j.jconrel.2017.07.047 [doi]
PST - ppublish
SO  - J Control Release. 2017 Sep 28;262:329-347. doi: 10.1016/j.jconrel.2017.07.047. 
      Epub 2017 Aug 2.